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measure Genotyping array and DNA exome array
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R Early pregnancy Mid pregnancy Late pregnancy BirthAssessment of single nucleotide polymorphisms (SNPs) as obtained through genotyping arrays.Created June 5, 2024 • Updated September 19, 2024 -
measure Lung function - Spirometry
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 9-10 years 13-14 yearsLung function was measured by spirometry. Measures included FEV1, forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow at 75% of FVC (FEF75).Created June 5, 2024 • Updated September 19, 2024 -
measure Skinfold thickness, waist and hip circumference
Study: Generation R Mode of collection: MeasurementsAndTests Anthropometrics/Body measures Available measurements: Generation R 6 weeks 6 months 1 year 2 years 3 years 4 yearsSkinfold thickness, waist and hip circumference were assessed as an indication of body fat. Skinfold thickness can noninvasively and reliably be measured at various sites of the body using a skinfold caliper. Based on measurements at multiple sites of the body, the total body fat and contribution of fat to the body mass can be estimated.Created June 5, 2024 • Updated September 19, 2024 -
measure Electrocardiography (ECG)
Study: Generation R Mode of collection: MeasurementsAndTests ECG Available measurements: Generation R 17-18 yearsElectrocardiography (ECG) is a medical diagnostic technique that records the electrical activity of the heart over time, enabling the assessment of its rhythm, rate, and overall cardiovascular health.Created June 5, 2024 • Updated September 19, 2024 -
measure LC-MS lipids
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R Early pregnancy Birth 9-10 yearsLiquid chromatography mass spectrometry (LC-MS) platform targeting lipid species.Created June 5, 2024 • Updated September 19, 2024 -
measure Body composition and bone mineral density (Dual X energy absorptiometry)
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 5-6 years 9-10 years 13-14 years 17-18 yearsDual X energy absorptiometry scans (iDXA; General Electric, formerly Lunar Corp., Madison, WI) were used to obtain measurements of bone and soft tissue for the total body and sub regions, including bone mineral content (g), fat mass (g), and lean mass (g).Created June 5, 2024 • Updated September 19, 2024 -
measure Dental plaque and oral microbiome
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 13-14 years 17-18 yearsDental plaque samples were collected by rubbing a cotton swab over the buccal sides of the right lower permanent molars. DNA was isolated from the dental plaque swabs.Created June 5, 2024 • Updated September 19, 2024 -
measure Lungs - Allergy test
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 9-10 yearsSensitization for birch, cat or dog, or five grass mixture was measured with skin prick tests. Allergy outcomes were categorized into the groups “no inhalant allergic sensitization, no physician-diagnosed inhalant allergy,” “inhalant allergic sensitization but no physician-diagnosed inhalant allergy,” “no inhalant allergic sensitization but...Created June 5, 2024 • Updated September 19, 2024 -
measure Genotyping (array)
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R BirthAssessment of micro-satellite markers, single nucleotide polymorphisms (SNP), and variable number (short) tandem repeats (VNTRs) as obtained through genotyping arrays.Created June 5, 2024 • Updated September 19, 2024 -
measure Bone mineral density and geometry of the tibia (Peripheral Quantitative Compu...
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 13-14 years 17-18 yearsMeasurements of bone mineral density and the Geometry of the tibia by peripheral quantitative computed tomography (CT).Created June 5, 2024 • Updated September 19, 2024 -
measure Urine sample
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R Early pregnancy Mid pregnancy Late pregnancy 5-6 years 9-10 years 13-14 years 17-18 yearsFirst-morning, spot, or 24 hour urine sample.Created June 5, 2024 • Updated September 19, 2024 -
measure Airway inflammation and airway resistance
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 5-6 yearsAirway interrupter resistance (Rint) was measured in kilo-pascals per liter during tidal expiration, with occlusion of the airway at peak expiratory flow. Fractional exhaled nitric oxide (FeNO) in parts per billion (ppb) was measured using the NIOX chemiluminescence analyzer.Created June 5, 2024 • Updated September 19, 2024 -
measure Heart ultrasound
Study: Generation R Mode of collection: MeasurementsAndTests Echo Available measurements: Generation R 5-6 yearsHeart ultrasound, also known as echocardiography, is a non-invasive medical imaging technique that uses sound waves to create real-time images of the heart's structures, chambers, valves, and blood flow, providing information about its functioning and potential abnormalities.Created June 5, 2024 • Updated September 19, 2024 -
measure Muscle function and bone strength (Mechanography)
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 17-18 yearsMuscle function and bone strength were assessed using mechanography. This includes a mechanographic record of jumping movements on a specially designed springboard. Relevant functional parameters such as strength and spot force are measured to determine coordination, muscle function and muscle-bone relationship.Created June 5, 2024 • Updated September 19, 2024 -
measure Actigraphy
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 12 yearsActigraphy estimates children's sleep on both week and weekend days by wearing a tri-axial wrist accelerometer (GENEActiv, Activinsights, UK) for 9 subsequent days on their non-dominant wrist. From the actigraph, sleep duration, sleep efficiency, and sleep arousal can be assessed.Created June 5, 2024 • Updated September 19, 2024 -
measure Cordblood sample
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R BirthA cordblood sample consists of taking an amount of a person's blood from their umbilical cord. The umbilical cord is the rope-like structure that connects a mother to her unborn baby. After the cord is cut, a health care provider will use a tool called a clamp to stop the cord from bleeding. The provider will then use a needle to withdraw blood from the...Created June 5, 2024 • Updated September 19, 2024 -
measure Exercise test - Steep Ramp Test
Study: Generation R Mode of collection: MeasurementsAndTests Biological sample/measurement Available measurements: Generation R 13-14 yearsThe Steep Ramp Test is a short maximal exercise test that measures the peak work rate (WRpeak), which is a valid and reliable estimation of the maximal aerobic exercise capacity and thus cardiorespiratory fitness.Created June 5, 2024 • Updated September 19, 2024 -
measure Cardiac measurements - Magnetic Resonance Imaging
Study: Generation R Mode of collection: MeasurementsAndTests MRI Available measurements: Generation R 9-10 yearsMagnetic Resonance Imaging (MRI) scans were made to assess cardiac structure, diastolic volume, systolic volume, functional cardiac measurements, ejection fraction, stroke volume and aortic diameter.Created June 5, 2024 • Updated September 19, 2024 -
measure Dental development
Study: Generation R Mode of collection: MeasurementsAndTests X-ray Available measurements: Generation R 9-10 years 13-14 yearsPanoramic radiographs were used to ascertain dental development.Created June 5, 2024 • Updated September 19, 2024 -
measure Gangliothalamic ovoid diameter and ventricular volume
Study: Generation R Mode of collection: MeasurementsAndTests Echo Available measurements: Generation R 6 weeksCranial ultrasound measurements were performed to obtain gangliothalamic ovoid diameter and ventricular volume.Created June 5, 2024 • Updated September 19, 2024