• measure Genotyping array and DNA exome array

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Late pregnancy Birth
     
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    Assessment of single nucleotide polymorphisms (SNPs) as obtained through genotyping arrays.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Lung function - Spirometry

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  9-10 years 13-14 years
     
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    Lung function was measured by spirometry. Measures included FEV1, forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow at 75% of FVC (FEF75).
    Created October 17, 2024 • Updated October 20, 2024

  • measure LC-MS lipids

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Birth 9-10 years
     
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    Liquid chromatography mass spectrometry (LC-MS) platform targeting lipid species.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Body composition and bone mineral density (Dual X energy absorptiometry)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  5-6 years 9-10 years 13-14 years 17-18 years
     
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    Dual X energy absorptiometry scans (iDXA; General Electric, formerly Lunar Corp., Madison, WI) were used to obtain measurements of bone and soft tissue for the total body and sub regions, including bone mineral content (g), fat mass (g), and lean mass (g).
    Created October 17, 2024 • Updated October 20, 2024

  • measure Dental plaque and oral microbiome

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years 17-18 years
     
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    Dental plaque samples were collected by rubbing a cotton swab over the buccal sides of the right lower permanent molars. DNA was isolated from the dental plaque swabs.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Lungs - Allergy test

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  9-10 years
     
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    Sensitization for birch, cat or dog, or five grass mixture was measured with skin prick tests. Allergy outcomes were categorized into the groups “no inhalant allergic sensitization, no physician-diagnosed inhalant allergy,” “inhalant allergic sensitization but no physician-diagnosed inhalant allergy,” “no inhalant allergic sensitization but...
    Created October 17, 2024 • Updated October 20, 2024

  • measure Genotyping (array)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Birth
     
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    Assessment of micro-satellite markers, single nucleotide polymorphisms (SNP), and variable number (short) tandem repeats (VNTRs) as obtained through genotyping arrays.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Bone mineral density and geometry of the tibia (Peripheral Quantitative Compu...

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years 17-18 years
     
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    Measurements of bone mineral density and the Geometry of the tibia by peripheral quantitative computed tomography (CT).
    Created October 17, 2024 • Updated October 20, 2024

  • measure Urine sample

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Late pregnancy 5-6 years 9-10 years 13-14 years 17-18 years
     
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    First-morning, spot, or 24 hour urine sample.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Airway inflammation and airway resistance

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  5-6 years
     
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    Airway interrupter resistance (Rint) was measured in kilo-pascals per liter during tidal expiration, with occlusion of the airway at peak expiratory flow. Fractional exhaled nitric oxide (FeNO) in parts per billion (ppb) was measured using the NIOX chemiluminescence analyzer.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Muscle function and bone strength (Mechanography)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  17-18 years
     
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    Muscle function and bone strength were assessed using mechanography. This includes a mechanographic record of jumping movements on a specially designed springboard. Relevant functional parameters such as strength and spot force are measured to determine coordination, muscle function and muscle-bone relationship.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Actigraphy

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  12 years
     
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    Actigraphy estimates children's sleep on both week and weekend days by wearing a tri-axial wrist accelerometer (GENEActiv, Activinsights, UK) for 9 subsequent days on their non-dominant wrist. From the actigraph, sleep duration, sleep efficiency, and sleep arousal can be assessed.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Cordblood sample

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Birth
     
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    A cordblood sample consists of taking an amount of a person's blood from their umbilical cord. The umbilical cord is the rope-like structure that connects a mother to her unborn baby. After the cord is cut, a health care provider will use a tool called a clamp to stop the cord from bleeding. The provider will then use a needle to withdraw blood from the...
    Created October 17, 2024 • Updated October 20, 2024

  • measure Exercise test - Steep Ramp Test

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years
     
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    The Steep Ramp Test is a short maximal exercise test that measures the peak work rate (WRpeak), which is a valid and reliable estimation of the maximal aerobic exercise capacity and thus cardiorespiratory fitness.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Audiometry

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  9-10 years 13-14 years 17-18 years
     
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    years
    Audiometry measurements evaluate an individual's hearing abilities, with pure-tone audiometry assessing hearing sensitivity across different frequencies and intensities, and tympanometry measuring the middle ear's response to changes in air pressure.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Blood sample

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Birth 6 months 1 year 1.5 years 2 years 3 years 5-6 years 8 years 9-10 years 13-14 years 17-18 years
     
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    A blood sample consists of taking an amount of a person's blood from their body.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Neuromotor development

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  6 weeks 3 months 6 months 1 year
     
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    Neuromotor development was assessed using items from the Touwen’s Neurodevelopmental Examination. Children's motor behavior was observed in supine, prone, sitting, standing, and walking positions.
    Created October 17, 2024 • Updated October 20, 2024

  • measure Glucose metabolism

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Birth 5-6 years
     
    0
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    Blood sugar markers, for instance Glucose, Insulin, and C-peptide, measured with traditional enzymatic tests, such as Enzyme-Linked Immunosorbent Assays (ELISA).
    Created October 17, 2024 • Updated October 20, 2024

  • measure Blood pressure

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Late pregnancy 6 weeks 6 months 1 year 2 years 3 years 4 years 5-6 years 9-10 years 13-14 years 17-18 years
     
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    years
    Blood pressure is the force of blood pushing against the walls of arteries as the heart pumps blood around the body. Systolic pressure is the pressure when the heart contracts and pushes blood out and diastolic pressure is the pressure when the heart relaxes and fills with blood. In adults, the systolic pressure normally ranges between 80 and 120 and the...
    Created October 17, 2024 • Updated October 20, 2024

  • measure Nasal and nasalpharyngeal swab

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  6 weeks 6 months 1 year 2 years 3 years 5-6 years 9-10 years
     
    0
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    Nasal and nasalpharyngeal samples were taken by the use of swabs that were rubbed through the nostrils and the upper part of the throat located behind the nasal cavity. Colonization with Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis was determined afterwards.
    Created October 17, 2024 • Updated October 20, 2024
You can also access this registry using the API (see API Docs).