Airway inflammation and airway resistance
Airway interrupter resistance (Rint) was measured in kilo-pascals per liter during tidal expiration, with occlusion of the airway at peak expiratory flow. Fractional exhaled nitric oxide (FeNO) in parts per billion (ppb) was measured using the NIOX chemiluminescence analyzer.
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4.9 - 9.1 years From 2008-01-01 to 2012-12-31 |
| Mode of collection | MeasurementsAndTests Biological sample/measurement |
| Analysis unit | Individual |
| Instrument name | Airway inflammation and airway resistance |
| Measure name | Fractional exhaled nitric oxide and interrupter technique |
Measure was collected within the following cohort study:
The Generation R Study Cohort study
| Purpose | The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. |
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| Time method | Longitudinal |
| Universe | Youth, and their parents, from the general population followed since prenatal life until young adulthood, all born in Rotterdam, the Netherlands. |
Measure was collected within the following cohort(s):
Generation R: Generation R Cohort
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| Description | The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. |
| Purpose | The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. |
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| Country code | NL |
| Geographic location | 3010-3070 |
| Lowest geographic reference | postal code |
| Highest geographic reference | city |
| Cohort universe description | Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. |
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| Time method | Longitudinal.CohortEventBased |
Measure was collected within the following wave(s):
5-6 years Wave
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| Short description of the wave | The 5-6 years wave consisted of questionnaires (parent and teacher reports) and a visit to the research center around the age of 6 years (full sample; mean age: 6.1 years). Among a selected subsample, there was also a home visit including the DISC (a psychiatric interview). |
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| (sub) cohort | Generation R: Generation R |
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| Start date wave collection | 2008-01-01 |
| End date wave collection | 2012-12-31 |
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| Description of physical data product | Digital files, biological samples |
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| author | None |
| author_email | None |
| creator_user_id | 34768773-4537-4d74-8d9d-11e2b32cbbaf |
| dc_analysis_unit | {Individual} |
| dc_cohort | GenR |
| dc_instrument_name | Airway inflammation and airway resistance |
| dc_measure_name | Fractional exhaled nitric oxide and interrupter technique |
| id | 25da507c-103c-4613-9dd6-4a2766fb0248 |
| isopen | False |
| license_title | None |
| maintainer | None |
| maintainer_email | None |
| metadata_created | 2024-10-17T12:33:05.494152 |
| metadata_modified | 2024-10-20T12:49:10.734495 |
| name | 07e6073edf9e32b714357b89511de314 |
| notes | Airway interrupter resistance (Rint) was measured in kilo-pascals per liter during tidal expiration, with occlusion of the airway at peak expiratory flow. Fractional exhaled nitric oxide (FeNO) in parts per billion (ppb) was measured using the NIOX chemiluminescence analyzer. |
| num_resources | 0 |
| num_tags | 0 |
| organization | {'id': '8dee8702-82b1-4d76-ba66-bdb5f4b47fa4', 'name': 'gen-r', 'title': 'Generation R', 'type': 'organization', 'description': 'The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood.', 'image_url': 'https://data.individualdevelopment.nl/img/logo_genr.png', 'created': '2024-10-17T13:43:46.407045', 'is_organization': True, 'approval_status': 'approved', 'state': 'active'} |
| owner_org | 8dee8702-82b1-4d76-ba66-bdb5f4b47fa4 |
| private | False |
| state | active |
| title | Airway inflammation and airway resistance |
| type | measure |
| cohort | [{'cohort_alternate_title': ['GenR ', 'Gen-R'], 'cohort_description': 'The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. 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'0000-0002-4395-1397'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Uitterlinden, A.G.', 'cohort_creator_pid': '0000-0002-7276-3387'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': '', 'cohort_creator_identifier_type': '', 'cohort_creator_name': 'Vis, J.Y.', 'cohort_creator_pid': ''}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 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'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Voortman, T.', 'cohort_creator_pid': '0000-0003-2830-6813'}, {'cohort_creator_affiliation': 'GGD Rotterdam-Rijnmond', 'cohort_creator_affiliation_identifier': 'https://ror.org/00dkp4z50', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'de Wilde, E.J.', 'cohort_creator_pid': '0000-0001-6009-0608'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Wildschut, H.', 'cohort_creator_pid': '0000-0003-3506-3944'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': '', 'cohort_creator_identifier_type': '', 'cohort_creator_name': 'Witteman, J.C.M.', 'cohort_creator_pid': ''}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Wolvius, E.B.', 'cohort_creator_pid': '0000-0002-5159-3497'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'van Schaik, R.H.N.', 'cohort_creator_pid': '0000-0003-1864-2151'}], 'cohort_funding': [{'cohort_funder': 'All funders are listed via the Generation R website', 'cohort_funder_identifier': 'https://generationr.nl/algemeen/donateurs/', 'cohort_funder_identifier_type': 'url'}], 'cohort_publisher': [{'cohort_publisher_identifier': 'https://ror.org/018906e22', 'cohort_publisher_identifier_type': 'ROR', 'cohort_publisher_name': 'Erasmus MC'}], 'cohort_references': [{'cohort_reference_citation': 'Growth, development and health from early fetal life until young adulthood: the Generation R Study', 'cohort_reference_identifier': 'https://doi.org/10.1111/j.1365-3016.2003.00521.x', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': '\xa0The Generation R Study: Design and cohort profile', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-006-9022-0', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study Biobank: a resource for epidemiological studies in children and their parents', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-007-9209-z', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: design and cohort update until the age of 4 years', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-008-9309-4', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: design and cohort update 2010', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-010-9516-7', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': '\xa0The Generation R Study: design and cohort update 2012', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-012-9735-1', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'Pediatric population-based neuroimaging and the Generation R Study: the intersection of developmental neuroscience and epidemiology', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-013-9768-0', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: Biobank update 2015', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-014-9980-6', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: design and cohort update 2017', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-016-0224-9', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}]}] |
| dc_DOI | [{'dc_identifier_type': 'DOI', 'dc_pid': '10.60641/5edj-tn50'}] |
| dc_constructs | [{'dc_construct': 'physiology'}] |
| dc_labels | [{'dc_label': 'lung function'}, {'dc_label': 'airway inflammation'}, {'dc_label': 'airway resistance'}, {'dc_label': 'airway interrupter resistance'}, {'dc_label': 'tidal expiration'}, {'dc_label': 'airway occlusion'}] |
| dc_modes_of_collection | [{'dc_mode_of_collection': 'MeasurementsAndTests'}] |
| dc_modes_of_collection_sub | [{'dc_mode_of_collection_sub': 'Biological sample/measurement'}] |
| measure_age_range | [{'measure_age_month': 59}, {'measure_age_month': 60}, {'measure_age_month': 61}, {'measure_age_month': 62}, {'measure_age_month': 63}, {'measure_age_month': 64}, {'measure_age_month': 65}, {'measure_age_month': 66}, {'measure_age_month': 67}, {'measure_age_month': 68}, {'measure_age_month': 69}, {'measure_age_month': 70}, {'measure_age_month': 71}, {'measure_age_month': 72}, {'measure_age_month': 73}, {'measure_age_month': 74}, {'measure_age_month': 75}, {'measure_age_month': 76}, {'measure_age_month': 77}, {'measure_age_month': 78}, {'measure_age_month': 79}, {'measure_age_month': 80}, {'measure_age_month': 81}, {'measure_age_month': 82}, {'measure_age_month': 83}, {'measure_age_month': 84}, {'measure_age_month': 85}, {'measure_age_month': 86}, {'measure_age_month': 87}, {'measure_age_month': 88}, {'measure_age_month': 89}, {'measure_age_month': 90}, {'measure_age_month': 91}, {'measure_age_month': 92}, {'measure_age_month': 93}, {'measure_age_month': 94}, {'measure_age_month': 95}, {'measure_age_month': 96}, {'measure_age_month': 97}, {'measure_age_month': 98}, {'measure_age_month': 99}, {'measure_age_month': 100}, {'measure_age_month': 101}, {'measure_age_month': 102}, {'measure_age_month': 103}, {'measure_age_month': 104}, {'measure_age_month': 105}, {'measure_age_month': 106}, {'measure_age_month': 107}, {'measure_age_month': 108}, {'measure_age_month': 109}] |
| study | [{'study_alternate_title': ['Generation R', 'Gen-R'], 'study_language': 'NL', 'study_purpose': 'The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.', 'study_time_method': 'Longitudinal', 'study_universe': 'Youth, and their parents, from the general population followed since prenatal life until young adulthood, all born in Rotterdam, the Netherlands.', 'title': 'The Generation R Study', 'study_contact': [{'study_contact_affiliation': 'Erasmus MC', 'study_contact_mail': 'generationr@erasmusmc.nl', 'study_contact_name': 'Generation R Data Management'}], 'study_contributor': [{'study_contributor_affiliation': 'Erasmus MC', 'study_contributor_affiliation_identifier': 'https://ror.org/018906e22', 'study_contributor_affiliation_identifier_scheme': 'ROR', 'study_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_contributor_identifier_type': 'url', 'study_contributor_name': 'The Generation R Study Group', 'study_contributor_pid': 'https://generationr.nl/algemeen/organisatie/'}], 'study_data_access': [{'study_data_access_URL': 'https://generationr.nl/', 'study_data_access_description': 'Data access requests can be directed to the data management team of the Generation R Study (generationr@erasmusmc.nl), which has a protocol for approving data requests. Because of restrictions based on privacy regulations and informed consent of participants, data cannot be made freely available in a public repository.'}], 'study_funding': [{'study_funder': 'All funders are listed via the Generation R website', 'study_funder_identifier': 'https://generationr.nl/algemeen/donateurs/', 'study_funder_identifier_type': 'url'}], 'study_principal_investigators': [{'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Bierma - Zeinstra, S.M.A.', 'study_pi_pid': '0000-0003-1280-5896'}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Bonsel, G.J.', 'study_pi_pid': '0000-0002-8364-1086'}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': '', 'study_pi_identifier_type': '', 'study_pi_name': 'Büller, H.A.', 'study_pi_pid': ''}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'van Duijn, C.M.', 'study_pi_pid': '0000-0002-2374-9204'}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Duijts, L.', 'study_pi_pid': '0000-0001-6731-9452'}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Felix, J.F.', 'study_pi_pid': '0000-0002-9801-5774'}, {'study_pi_affiliation': 'Erasmus MC', 'study_pi_affiliation_identifier': 'https://ror.org/018906e22', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': '', 'study_pi_identifier_type': '', 'study_pi_name': 'Franco, 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