• measure Genotyping array and DNA exome array

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Late pregnancy Birth
     
    0
    5
    10
    15
    20
    25
    30
    years
    Assessment of single nucleotide polymorphisms (SNPs) as obtained through genotyping arrays.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Lung function - Spirometry

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  9-10 years 13-14 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Lung function was measured by spirometry. Measures included FEV1, forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow at 75% of FVC (FEF75).
    Created June 5, 2024 • Updated September 19, 2024

  • measure Skinfold thickness, waist and hip circumference

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Anthropometrics/Body measures
    Available measurements:
    Generation R  6 weeks 6 months 1 year 2 years 3 years 4 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Skinfold thickness, waist and hip circumference were assessed as an indication of body fat. Skinfold thickness can noninvasively and reliably be measured at various sites of the body using a skinfold caliper. Based on measurements at multiple sites of the body, the total body fat and contribution of fat to the body mass can be estimated.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Electrocardiography (ECG)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    ECG
    Available measurements:
    Generation R  17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Electrocardiography (ECG) is a medical diagnostic technique that records the electrical activity of the heart over time, enabling the assessment of its rhythm, rate, and overall cardiovascular health.
    Created June 5, 2024 • Updated September 19, 2024

  • measure LC-MS lipids

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Birth 9-10 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Liquid chromatography mass spectrometry (LC-MS) platform targeting lipid species.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Body composition and bone mineral density (Dual X energy absorptiometry)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  5-6 years 9-10 years 13-14 years 17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Dual X energy absorptiometry scans (iDXA; General Electric, formerly Lunar Corp., Madison, WI) were used to obtain measurements of bone and soft tissue for the total body and sub regions, including bone mineral content (g), fat mass (g), and lean mass (g).
    Created June 5, 2024 • Updated September 19, 2024

  • measure Dental plaque and oral microbiome

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years 17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Dental plaque samples were collected by rubbing a cotton swab over the buccal sides of the right lower permanent molars. DNA was isolated from the dental plaque swabs.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Tanner Scale

    Study:Generation R
    Mode of collection: SelfAdministeredQuestionnaire
    Available measurements:
    Generation R  13-14 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    The Tanner Scale describes, both pictorially and descriptively, the external changes that occur in the time period between the onset of puberty and the achievement of full maturity for both girls and boys. Characterizations of pubertal status are assessed by breast development in girls, genital development in boys and pubic hair growth in both. The Tanner...
    Created June 5, 2024 • Updated September 19, 2024

  • measure Lungs - Allergy test

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  9-10 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Sensitization for birch, cat or dog, or five grass mixture was measured with skin prick tests. Allergy outcomes were categorized into the groups “no inhalant allergic sensitization, no physician-diagnosed inhalant allergy,” “inhalant allergic sensitization but no physician-diagnosed inhalant allergy,” “no inhalant allergic sensitization but...
    Created June 5, 2024 • Updated September 19, 2024

  • measure Genotyping (array)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Birth
     
    0
    5
    10
    15
    20
    25
    30
    years
    Assessment of micro-satellite markers, single nucleotide polymorphisms (SNP), and variable number (short) tandem repeats (VNTRs) as obtained through genotyping arrays.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Bone mineral density and geometry of the tibia (Peripheral Quantitative Compu...

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years 17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Measurements of bone mineral density and the Geometry of the tibia by peripheral quantitative computed tomography (CT).
    Created June 5, 2024 • Updated September 19, 2024

  • measure Urine sample

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Early pregnancy Mid pregnancy Late pregnancy 5-6 years 9-10 years 13-14 years 17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    First-morning, spot, or 24 hour urine sample.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Airway inflammation and airway resistance

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  5-6 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Airway interrupter resistance (Rint) was measured in kilo-pascals per liter during tidal expiration, with occlusion of the airway at peak expiratory flow. Fractional exhaled nitric oxide (FeNO) in parts per billion (ppb) was measured using the NIOX chemiluminescence analyzer.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Heart ultrasound

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Echo
    Available measurements:
    Generation R  5-6 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Heart ultrasound, also known as echocardiography, is a non-invasive medical imaging technique that uses sound waves to create real-time images of the heart's structures, chambers, valves, and blood flow, providing information about its functioning and potential abnormalities.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Muscle function and bone strength (Mechanography)

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  17-18 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Muscle function and bone strength were assessed using mechanography. This includes a mechanographic record of jumping movements on a specially designed springboard. Relevant functional parameters such as strength and spot force are measured to determine coordination, muscle function and muscle-bone relationship.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Actigraphy

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  12 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Actigraphy estimates children's sleep on both week and weekend days by wearing a tri-axial wrist accelerometer (GENEActiv, Activinsights, UK) for 9 subsequent days on their non-dominant wrist. From the actigraph, sleep duration, sleep efficiency, and sleep arousal can be assessed.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Cordblood sample

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  Birth
     
    0
    5
    10
    15
    20
    25
    30
    years
    A cordblood sample consists of taking an amount of a person's blood from their umbilical cord. The umbilical cord is the rope-like structure that connects a mother to her unborn baby. After the cord is cut, a health care provider will use a tool called a clamp to stop the cord from bleeding. The provider will then use a needle to withdraw blood from the...
    Created June 5, 2024 • Updated September 19, 2024

  • measure Exercise test - Steep Ramp Test

    Study:Generation R
    Mode of collection: MeasurementsAndTests    Biological sample/measurement
    Available measurements:
    Generation R  13-14 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    The Steep Ramp Test is a short maximal exercise test that measures the peak work rate (WRpeak), which is a valid and reliable estimation of the maximal aerobic exercise capacity and thus cardiorespiratory fitness.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Cardiac measurements - Magnetic Resonance Imaging

    Study:Generation R
    Mode of collection: MeasurementsAndTests    MRI
    Available measurements:
    Generation R  9-10 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Magnetic Resonance Imaging (MRI) scans were made to assess cardiac structure, diastolic volume, systolic volume, functional cardiac measurements, ejection fraction, stroke volume and aortic diameter.
    Created June 5, 2024 • Updated September 19, 2024

  • measure Dental development

    Study:Generation R
    Mode of collection: MeasurementsAndTests    X-ray
    Available measurements:
    Generation R  9-10 years 13-14 years
     
    0
    5
    10
    15
    20
    25
    30
    years
    Panoramic radiographs were used to ascertain dental development.
    Created June 5, 2024 • Updated September 19, 2024
You can also access this registry using the API (see API Docs).