DNA methylation (candidate genes)
DNA methylation of selected candidate genes, such as Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), Solute Carrier Family 6 Member 4 (SLC6A4), and Catechol-O-Methyltransferase (COMT).
In Generation R, DNA methylation was determined from cord blood samples.
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0 months From 2002-01-01 to 2006-12-31 |
| Mode of collection | MeasurementsAndTests Biological sample/measurement |
| Analysis unit | Individual |
| Instrument name | Candidate gene methylation |
| References |
Measure was collected within the following cohort study:
| Purpose | The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. |
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| Time method | Longitudinal |
| Universe | Youth, and their parents, from the general population followed since prenatal life until young adulthood, all born in Rotterdam, the Netherlands. |
Measure was collected within the following cohort(s):
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| Description | The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. |
| Purpose | The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children. |
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| Country code | NL |
| Geographic location | 3010-3070 |
| Lowest geographic reference | postal code |
| Highest geographic reference | city |
| Cohort universe description | Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. |
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| Time method | Longitudinal.CohortEventBased |
Measure was collected within the following wave(s):
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| Short description of the wave | The Birth wave consisted of data from birth records and cord blood samples taken at birth. |
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| (sub) cohort | Generation R: Generation R |
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| Start date wave collection | 2002-01-01 |
| End date wave collection | 2006-12-31 |
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| Description of physical data product | Digital files, biological samples |
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| author | None |
| author_email | None |
| creator_user_id | 34768773-4537-4d74-8d9d-11e2b32cbbaf |
| dc_additional_info | In Generation R, DNA methylation was determined from cord blood samples. |
| dc_analysis_unit | {Individual} |
| dc_cohort | GenR |
| dc_common_id | 0105_CD2 |
| dc_instrument_name | Candidate gene methylation |
| id | 88e4d079-bbd2-4802-ab9b-357e5fb186ff |
| isopen | False |
| license_title | None |
| maintainer | None |
| maintainer_email | None |
| metadata_created | 2024-10-17T12:27:42.957934 |
| metadata_modified | 2024-10-20T12:44:47.053136 |
| name | fa0c6e86b21abaf059591d7838026c21 |
| notes | DNA methylation of selected candidate genes, such as Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1), Solute Carrier Family 6 Member 4 (SLC6A4), and Catechol-O-Methyltransferase (COMT). |
| num_resources | 0 |
| num_tags | 0 |
| organization | {'id': '8dee8702-82b1-4d76-ba66-bdb5f4b47fa4', 'name': 'gen-r', 'title': 'Generation R', 'type': 'organization', 'description': 'The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood.', 'image_url': 'https://data.individualdevelopment.nl/img/logo_genr.png', 'created': '2024-10-17T13:43:46.407045', 'is_organization': True, 'approval_status': 'approved', 'state': 'active'} |
| owner_org | 8dee8702-82b1-4d76-ba66-bdb5f4b47fa4 |
| private | False |
| state | active |
| title | DNA methylation (candidate genes) |
| type | measure |
| cohort | [{'cohort_alternate_title': ['GenR ', 'Gen-R'], 'cohort_description': 'The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. ', 'cohort_language': 'NL', 'cohort_purpose': 'The purposes of the Generation R study are to (1) describe normal and abnormal growth, development and health from early fetal life to adulthood in a multi-ethnic population; (2) identify (epi-)genetic, biological, social and environmental determinants of this normal and abnormal growth, development and health; and (3) contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.', 'cohort_spatial_country_code': 'NL', 'cohort_spatial_geographic_location': '3010-3070', 'cohort_spatial_highest_reference': 'city', 'cohort_spatial_lowest_reference': 'postal code', 'cohort_time_method': 'Longitudinal.CohortEventBased', 'cohort_title': 'Generation R: Generation R', 'cohort_universe': 'Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood. 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'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'van Duijn, C.M.', 'cohort_creator_pid': '0000-0002-2374-9204'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Duijts, L.', 'cohort_creator_pid': '0000-0001-6731-9452'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Felix, J.F.', 'cohort_creator_pid': '0000-0002-9801-5774'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': '', 'cohort_creator_identifier_type': '', 'cohort_creator_name': 'Franco, O.H.', 'cohort_creator_pid': ''}, {'cohort_creator_affiliation': 'Erasmus University Rotterdam', 'cohort_creator_affiliation_identifier': 'https://ror.org/057w15z03', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Franken, I.H.A.', 'cohort_creator_pid': '0000-0002-7853-2694'}, {'cohort_creator_affiliation': 'Erasmus MC', 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'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': '', 'cohort_creator_identifier_type': '', 'cohort_creator_name': 'van der Heijden, A.J.', 'cohort_creator_pid': ''}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Hillegers, M.H.J.', 'cohort_creator_pid': '0000-0003-4877-282X'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Hofman, A.', 'cohort_creator_pid': '0000-0002-9865-121X'}, {'cohort_creator_affiliation': 'Erasmus University Rotterdam', 'cohort_creator_affiliation_identifier': 'https://ror.org/057w15z03', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'van IJzendoorn, M.H.', 'cohort_creator_pid': '0000-0003-1144-454X'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Ikram, M.A.', 'cohort_creator_pid': '0000-0003-0372-8585'}, 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'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Moll, H.A.', 'cohort_creator_pid': '0000-0001-9898-923X'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Nijsten, T.', 'cohort_creator_pid': '0000-0001-9940-2875'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': '', 'cohort_creator_identifier_type': '', 'cohort_creator_name': 'Pardo Cortes, L.', 'cohort_creator_pid': ''}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Peeters, R.P.', 'cohort_creator_pid': '0000-0002-1226-2011'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Raat, H.', 'cohort_creator_pid': '0000-0002-6000-7445'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Reiss, I.K.M.', 'cohort_creator_pid': '0000-0002-9474-6895'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'de Rijke, Y.B.', 'cohort_creator_pid': '0000-0001-7759-4968'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'van Rijn, B.B.', 'cohort_creator_pid': '0000-0003-1305-3825'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Rings, E.H.', 'cohort_creator_pid': '0000-0001-8195-4356'}, {'cohort_creator_affiliation': 'Erasmus MC', 'cohort_creator_affiliation_identifier': 'https://ror.org/018906e22', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 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'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': '\xa0The Generation R Study: design and cohort update 2012', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-012-9735-1', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'Pediatric population-based neuroimaging and the Generation R Study: the intersection of developmental neuroscience and epidemiology', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-013-9768-0', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: Biobank update 2015', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-014-9980-6', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'The Generation R Study: design and cohort update 2017', 'cohort_reference_identifier': 'https://doi.org/10.1007/s10654-016-0224-9', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}]}] |
| dc_DOI | [{'dc_identifier_type': 'DOI', 'dc_pid': '10.60641/sawc-c424'}] |
| dc_constructs | [{'dc_construct': 'physiology'}] |
| dc_labels | [{'dc_label': 'omics'}, {'dc_label': 'genomics'}, {'dc_label': 'epigenetics'}, {'dc_label': 'dna'}, {'dc_label': 'catecholamine'}, {'dc_label': 'glucocorticoid receptor gene'}, {'dc_label': 'serotonin transporter gene'}] |
| dc_measurement_references | [{'dc_measurements_references_citation': 'Kruithof, C. J., Kooijman, M. N., van Duijn, C. M., Franco, O. H., de Jongste, J. C., Klaver, C. C. W., Mackenbach, J. P., Moll, H. A., Raat, H., Rings, E. H. H. M., Rivadeneira, F., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., Wolvius, E. B., Hofman, A., & Jaddoe, V. W. V. (2014). The Generation R Study: Biobank update 2015. European Journal of Epidemiology, 29(12), 911–927. https://doi.org/10.1007/s10654-014-9980-6\n', 'dc_measurements_references_doi': 'https://doi.org/10.1007/s10654-014-9980-6'}] |
| dc_modes_of_collection | [{'dc_mode_of_collection': 'MeasurementsAndTests'}] |
| dc_modes_of_collection_sub | [{'dc_mode_of_collection_sub': 'Biological sample/measurement'}] |
| measure_age_range | [{'measure_age_month': 0}] |
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