Dataset

Zygosity (DNA)

Zygosity typing based on micro-satellite markers, single nucleotide polymorphisms (SNP), or variable number (short) tandem repeats (VNTRs).

In NTR projects YC_ACTIONBB1_1, YC_ACTIONBB1_2, YC_ACTIONBB2, and YC_ACTIONBB3, YC_BS1, YC_BS2, YC_BS3, YC_DSC, YE_FITNSS, YE_ATTEF1, YE_ATTEF2, YE_ATTEF3, YC_ADHMI, and YE_COG18, as well as in the majority of the YNTR families (collection ongoing outside of mentioned subprojects), DNA is collected by buccal swabs. Zygosity typing was initially based on micro-satellite markers or relatively small numbers of SNPs and is now based on a larger number of SNPs and some repeat polymorphisms in a set of candidate genes. Different sets of SNPs and variable number tandem repeats (VNTRs) in candidate genes have been used over time (see: https://doi.org/10.1017/thg.2012.118). Besides, in NTR projects YS_3, YS_5, YS_7, YS_10, YS_12, YS_TRIP1_2, YS_TRIP3, YS_TRIP4, YS_TRIP5, YS_TRIP7, YS_TRIP10, and YS_TRIP12, parent-reported zygosity confirmation by DNA/blood testing was included in the survey. In NTR projects YC_DSC and YC_ADHMRI, mother-reported zygosity confirmation by DNA/blood testing was included in the telephone interview, and in NTR projects YS_DHBQ14 and YS_DHBW16, self-reported zygosity confirmation by DNA/blood testing was included in the survey as well.

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Keywords	dna zygosity monozygosity dizygosity buccal sample genetics physical similarity twinning
Constructs	physiology
Waves	Young Netherlands Twin Register YS_3 MC FC 36 months From 1990-01-01 (ongoing) YS_5 MC 5.0 years From 1994-01-01 (ongoing) YS_7 MC FC 7.0 years From 1995-01-01 (ongoing) YS_10 MC FC 9.0 - 10.0 years From 1997-01-01 (ongoing) YS_12 MC FC 12.0 years From 1998-01-01 (ongoing) YS_DHBQ14 CC 14.0 years From 2005-01-01 to 2013-01-01 YS_DHBQ16 CC 16.0 years From 2005-01-01 to 2013-01-01 YC_ACTION BB1_1 C 10.0 - 13.0 years From 2014-01-01 to 2015-01-01 YC_ACTION BB1_2 C 10.0 - 13.0 years From 2014-01-01 to 2015-01-01 YC_ACTION BB2 C 6.0 - 11.0 years From 2015-01-01 to 2015-01-01 YC_ACTION - BB3 C 6.0 - 13.0 years From 2016-01-01 to 2017-01-01 YC_BS1 C 9.0 years From 2005-01-01 to 2005-01-01 YC_BS2 C 12.0 years From 2007-01-01 to 2009-01-01 YC_BS3 C 17.0 years From 2012-01-01 to 2014-01-01 YC_DSC MC C 10.0 - 13.0 years From 2002-01-01 to 2005-01-01 YE_FITNSS C 16.0 - 18.0 years From 2012-01-01 to 2014-01-01 YE_ATTEF1 C 5.0 - 6.0 years From 1995-01-01 to 1996-01-01 YE_ATTEF2 C 12.0 years From 2002-01-01 to 2004-01-01 YE_ATTEF3 C 15.0 - 23.0 years From 2007-01-01 to 2010-01-01 YC_ADHMRI MC C 15.0 years From 2003-01-01 to 2007-01-01 YE_COG18 C 18.0 years From 2004-01-01 to 2006-01-01 YS_TRIP age 1-2 MC 24 months - 38.0 years From 2008-01-01 (ongoing) YS_TRIP age 3 MC FC 36 months From 1991-01-01 (ongoing) YS_TRIP age 4 MC FC 4.0 years From 1998-01-01 to 2011-01-01 YS_TRIP age 5 MC FC 5.0 years From 1991-01-01 (ongoing) YS_TRIP age 7 MC FC 7.0 years From 1998-01-01 (ongoing) YS_TRIP age 10 MC FC 9.0 - 10.0 years From 1998-01-01 (ongoing) YS_TRIP age 12 MC FC 12.0 years From 1998-01-01 (ongoing)
Mode of collection	MeasurementsAndTests Biological sample/measurement
Analysis unit	Individual
References	van Beijsterveldt, C. E. M., Groen-Blokhuis, M., Hottenga, J. J., Franić, S., Hudziak, J. J., Lamb, D., Huppertz, C., de Zeeuw, E., Nivard, M., Schutte, N., Swagerman, S., Glasner, T., van Fulpen, M., Brouwer, C., Stroet, T., Nowotny, D., Ehli, E. A., Davies, G. E., Scheet, P., … Boomsma, D. I. (2012). The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. Twin Research and Human Genetics, 16(1), 252–267. https://doi.org/10.1017/thg.2012.118

Purpose	The research carried out by the Netherlands Twin Register focuses on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.
description
Alternate title	NTR
Data access information	Researchers with an approved data sharing request who abide by the rules of the European General Data Protection Regulation can receive temporary access to the NTR data for their own research projects. https://ntr-data-request.psy.vu.nl/
Publisher	Vrije Universiteit Amsterdam
Principal investigators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Cohort study international identifier
Language	NL
Funding information	Dutch Research Council 480-15-001/674 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 575-25-006 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 480-04-004 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 911-09-032 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI
Contact information	NTR Data Management Vrije Universiteit Amsterdam ntr.datamanagement.fgb@vu.nl
References	Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420. Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212. van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620. Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148. Bartels M, van Beijsterveldt CE, Derks EM, Stroet TM, Polderman TJ, Hudziak JJ, Boomsma DI. Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. Twin Res Hum Genet. 2007 Feb;10(1):3-11. doi: 10.1375/twin.10.1.3.PMID: 17539360. Boomsma DI, Orlebeke JF, van Baal GC.Behav Genet. The Dutch Twin Register: growth data on weight and height. 1992 Mar;22(2):247-51. doi: 10.1007/BF01067004 Franić S, Dolan CV, van Beijsterveldt CE, Hulshoff Pol HE, Bartels M, Boomsma DI. Genetic and environmental stability of intelligence in childhood and adolescence. Twin Res Hum Genet. 2014 Jun;17(3):151-63. doi: 10.1017/thg.2014.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam
Time method	Longitudinal
Universe	The recruitment into the NTR is fully inclusive without any restrictions on enrolment. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR).

Alternate title	YNTR
Description	The Young Netherlands Twin Register (YNTR) consists of projects within the Netherlands Twin Register (NTR) that involve families with twins or other multiples under the age of 18.
Purpose	The purpose of the projects within the Young Netherlands Twin Register focus on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Language	NL
Cohort international identifier
Funding information	Dutch Research Council 480-15-001/674 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 575-25-006 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 480-04-004 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 911-09-032 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
Cohort reference papers
Classification
Contact information
Waves
Contributors	YNTR administration Vrije Universiteit Amsterdam
References	Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420. Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212. van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620. Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.
Country code	NL
Geographic location
Lowest geographic reference	postal code
Highest geographic reference	country
Cohort universe description	Families with twins or other multiples under the age of 18.
Analysis unit
Additional info (URL)
Additional information
Time method	Longitudinal.CohortEventBased

Measure was collected within the following wave(s):

YS_3 Wave

Wave alternate title	YNTR survey age 3 YS_3
Short description of the wave	The YS_3 survey is sent to both parents around the 3rd birth year of the twins (mean age = 3.35 years, SD = 0.275 years). The survey includes the CBCL 1.5-5, items on zygosity, health, growth data as obtained from the Dutch National Health Services, child care, demographic characteristics, including religious background and parental education and occupation. From 2009 onwards, additional items on well-being, leisure activities, sport activities and life events of the parents are included.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	165 Funder identifier Identifier type URI Funder award title Funder award URI
References	van der Valk, J. C. (2001). The Genetic and Environmental Contributions to Children's Problem Behaviors: A Developmental Approach. https://research.vu.nl/en/publications/the-genetic-and-environmental-contributions-to-childrens-problem-. ISBN: 90-9014842-6.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1990-01-01
End date wave collection
Wave universe description	36 months
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2016) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_5 Wave

Wave alternate title	YNTR survey age 5 YS_5
Short description of the wave	The YS_5 survey is sent to the mothers around the 5th birth year of the twins (mean age = 5.52 years, SD = 0.55 years). The survey includes items on child care and school, growth, zygosity, toilet training, asthma and eczema, fine motor coordination, language development, and problem behaviors as assessed by a short version of the Devereux Child Behavior Checklist (DCB). The booklet includes an extra section for fathers of twins to report about behavior problems. From 2011 onward, items on child care and school, living and family situation were updated and items on wellbeing were added. From the second half of 2015 the short form of the Childhood Behavior Questionnaire (CBQ) was added. From 2017 the surveys no longer have a separate section for the father.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1994-01-01
End date wave collection
Wave universe description	5.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data are digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_7 Wave

Wave alternate title	YNTR survey age 7 YS_7
Short description of the wave	The YS_7 survey collects information on the twins at age 7 (mean age = 7.47 years, SD = 0.40 years) from both parents and targets the development of emotional and behavior problems, as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, vaccinations, tonsillectomy (from 2005), demographic characteristics, growth, sport and leisure activity of both children and parents, and additional items on wellbeing (from 2010). In 2017 the survey was considerably shortened (for example the Conners was removed).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	165 Funder identifier Identifier type URI Funder award title Funder award URI
References	Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212. van der Valk, J. C. (2001). The Genetic and Environmental Contributions to Children's Problem Behaviors: A Developmental Approach. https://research.vu.nl/en/publications/the-genetic-and-environmental-contributions-to-childrens-problem-. ISBN: 90-9014842-6.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1995-01-01
End date wave collection
Wave universe description	7.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_10 Wave

Wave alternate title	YNTR survey age 9/10 YS_10
Short description of the wave	The YNTR survey 9/10 targets the development of emotional and behavior problems in 9-10 year old twins (mean age = 9.9 years, SD = 0.52 years), as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, vaccinations, tonsillectomy (from 2005), demographic characteristics, growth, sport and leisure activity of both children and parents, and additional items on wellbeing (from 2010).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References	Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1997-01-01
End date wave collection
Wave universe description	9.0 - 10.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_12 Wave

Wave alternate title	YNTR survey age 12 YS_12
Short description of the wave	The YNTR survey 12 was emailed to both parents of twins around the 12th birthday of the twins (mean age = 12.35 years, SD = 0.53 years). The survey targets the development of emotional and behavior problems as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, demographic characteristics, growth, sport and leisure activity of both children and parents (from 2003), and additional items on wellbeing (from 2008). In 2017 and 2018 the length of the questionnaire was shortened, the ASEBA Brief Problem Monitor (BPM) was used instead of the CBCL, and the 'cito survey' was added (see YS_CITO). From 2019, the questionnaire returned to its original length with CBCL and Conners items, and from 2020 the items on leisure time and on family and living situation were removed.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1998-01-01
End date wave collection
Wave universe description	12.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_DHBQ14 Wave

Wave alternate title	Dutch Health and Behavior Questionnaire - age 14 YS_DHBQ14
Short description of the wave	The Dutch Health and Behavior Questionnaire (DHBQ) was developed at the department of Biological Psychology of the VU University. It is a collection of standardized questions targeting multiple domains. The focus of the survey is on emotional and behavioral problems assessed by the Youth Self-Report (YSR), subjective wellbeing, lifestyle, exercise behavior, sedentary behavior, and family functioning. The YS_DHBQ14 project targeted 14-year old twins or triplets (mean age = 14.6 years, SD = 0.65 years) born between 1989 and 1999 and their 12-25 year old siblings (mean = 17.3 years, SD = 2.55 years) born between 1981 and 2001.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	463-06-001 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
References	van der Aa, N. (2011). Causes of variation in adolescent wellbeing. https://research.vu.nl/en/publications/causes-of-variation-in-adolescent-wellbeing. ISBN: 978-94-6169-009-8. Huppertz, C. (2016). How voluntary exercise behavior runs in families: Twin studies and beyond. https://research.vu.nl/en/publications/how-voluntary-exercise-behavior-runs-in-families-twin-studies-and. ISBN: 978-94-6299-314-3.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2005-01-01
End date wave collection	2013-01-01
Wave universe description	14.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2009) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam van der Aa, Niels Vrije Universiteit Amsterdam Huppertz, Charlotte Vrije Universiteit Amsterdam

YS_DHBQ16 Wave

Wave alternate title	Dutch Health and Behavior Questionnaire - age 16 YS_DHBQ16
Short description of the wave	The Dutch Health and Behavior Questionnaire (DHBQ) was developed at the department of Biological Psychology of the VU University. It is a collection of standardized questions targeting multiple domains. The focus of the survey is on emotional and behavioral problems assessed by the Youth Self-Report (YSR), subjective wellbeing, lifestyle, exercise behavior, sedentary behavior, and family functioning. From 2007, the survey includes the NEO Five Factor Inventory (NEO-FFI) and removed items regarding religion, stuttering, type of transportation to school, and hair/eye color. The YS_DHBQ16 project targeted 16-year old twins or triplets (mean age = 16.9 years, SD = 0.55 years) born between 1987 and 1999 and their 12-25 year old siblings (mean age = 18.5 years, SD = 3.34 years) born between 1981 and 2000.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	463-06-001 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
References	van der Aa, N. (2011). Causes of variation in adolescent wellbeing. https://research.vu.nl/en/publications/causes-of-variation-in-adolescent-wellbeing. ISBN: 978-94-6169-009-8. Huppertz, C. (2016). How voluntary exercise behavior runs in families: Twin studies and beyond. https://research.vu.nl/en/publications/how-voluntary-exercise-behavior-runs-in-families-twin-studies-and. ISBN: 978-94-6299-314-3.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2005-01-01
End date wave collection	2013-01-01
Wave universe description	16.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2009) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam van der Aa, Niels Vrije Universiteit Amsterdam Huppertz, Charlotte Vrije Universiteit Amsterdam

YC_ACTION BB1_1 Wave

Wave alternate title	Wave 1 Technical Pilot ACTION Biomarker Study YC_ACTION
Short description of the wave	The first wave of the technical pilot of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the technical pilot was to test the collection protocols for urine and buccal sample collection in 10-13 year old twins (mean age = 11.6 years, SD = 0.9 years) born between 2002 and 2005. The technical pilot comprised of twin participants with a low aggression score (T-score<65) on the mother-reported ASEBA CBCL Aggression Syndrome Scale at age 3 and/or age 7. Urine samples with minimal information regarding urine collection were collected at two timepoints with an interval of approximately two weeks. Urine samples contributed to the optimization of the biomarker assays and the liquid and gas chromatography mass spectrometry protocols for analyzing urine samples in children. In the technical pilot a urine dipstick and assessment of urine density (specific gravity) were obtained in addition to 15 biomarker assays (creatinine, neopterin, C-peptide, Substance P, Oxidized DNA/RNA, Procalcitonin, total antioxidant capacity, glucose, Thiobarbituric acid reactive species, beta-endorphin, cholecytokin, leu-enkaphalin, dynorphin A, albumin, and neurotensin) , and two metabolomics platforms (liquid chromatography mass spectrometry platform targeting amines and gas chromatography mass spectrometry platform targeting organic acids). Buccal-cell samples were also collected at both time points where samples obtained from wave 1 were genotyped on the Affymetrix Axiom genotyping array.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2014-01-01
End date wave collection	2015-01-01
Wave universe description	10.0 - 13.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YC_ACTION BB1_2 Wave

Wave alternate title	Wave 2 Technical Pilot ACTION Biomarker Study YC_ACTION
Short description of the wave	The second wave of the technical pilot of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the technical pilot was to test the collection protocols for urine and buccal sample collection in 10-13 year old twins born between 2002 and 2005 (mean age = 11.6 years, SD = 0.9 years). The technical pilot comprised twin participants with a low aggression score (T-score<65) on the mother-reported ASEBA CBCL Aggression Syndrome Scale at age 3 and/or age 7. Urine samples with minimal information regarding urine collection were collected at two timepoints with an interval of approximately two weeks. Urine samples contributed to the optimization of the biomarker assays and the liquid and gas chromatography mass spectrometry protocols for analyzing urine samples in children. In the technical pilot a urine dipstick and assessment of urine density (specific gravity) were obtained in addition to 15 biomarker assays (creatinine, neopterin, C-peptide, Substance P, Oxidized DNA/RNA, Procalcitonin, total antioxidant capacity, glucose, Thiobarbituric acid reactive species, beta-endorphin, cholecytokin, leu-enkaphalin, dynorphin A, albumin, and neurotensin), and two metabolomics platforms (liquid chromatography mass spectrometry platform targeting amines and gas chromatography mass spectrometry platform targeting organic acids). Buccal-cell samples were also collected at both time points where samples obtained from wave 1 were genotyped on the Affymetrix Axiom genotyping array.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2014-01-01
End date wave collection	2015-01-01
Wave universe description	10.0 - 13.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YC_ACTION BB2 Wave

Wave alternate title	Biochemical Study ACTION Biomarker Study YC_ACTION
Short description of the wave	The biochemical study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the biochemical study was to further validate the biomarker assays and metabolomics platforms selected during the two waves of the technical pilot (YC_ACTION BB1_1 BB1_2) in a larger sample of 6-11 year old twins born between 2004 and 2009 (mean age = 9.9 years, SD = 1.6 years). The twins were selected based on their mother-rated aggression scores (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist) at age 3 and/or 7. The Biochemical study comprised concordant low-scoring twin pairs, concordant high-scoring twin pairs, and a discordant low-high scoring twin pairs. High aggression was defined as having an ASEBA CBCL Aggression Syndrome Scale T-score equal to or larger than 65, and low aggression as an ASEBA CBCL Aggression Syndrome Scale T-score of less than 65. Here, data collection comprised of first-morning urine samples and buccal-cell DNA samples in the twins and family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, oxidized DNA/RNA, procalcitonin, total antioxidant capacity, and glucose, and two metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; and 2) a LC-MS platform targeting steroid hormones. Buccal-cell samples were genotyped on the Affymetrix Axiom genotyping array.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2015-01-01
End date wave collection	2015-01-01
Wave universe description	6.0 - 11.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YC_ACTION - BB3 Wave

Wave alternate title	Main Study ACTION Biomarker Study YC_ACTION
Short description of the wave	The Main Study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu), after the technical pilots (YC_ACTION BB1_1 and BB1_2) and the Biochemical study (YC_ACTION BB2). Here, data collection of first-morning urine samples for metabolomics biomarker discovery and buccal-cell DNA samples for (epi)genetics was conducted in a large cohort of 6-13 year old twins born between 2004 and 2011 (mean age = 9.5 years, SD = 1.9 years). Family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. The twins were selected to be part of a concordant low-scoring twin pair, a concordant high-scoring twin pair, or a discordant twin pair. Aggression had been assessed in the past by the age-appropriate version of the CBCL (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist). During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, and oxidized DNA/RNA. Metabolomics data of the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were were obtained from three metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; 2) a LC-MS platform targeting steroid hormones; and 3) a gas chromatography (GC) MS platform targeting organic acids. Buccal-cell samples of the twins from the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were used for genome-wide methylation measurement on the Infinium MethylationEPIC BeadChip Kit (after conclussion of the ACTION project additional twin pairs and siblings were also measured on this platform). DNA samples from all family members were genotyped on the Affymetrix Axiom or Illumina GSA genotyping arrays.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2016-01-01
End date wave collection	2017-01-01
Wave universe description	6.0 - 13.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YC_BS1 Wave

Wave alternate title	Brain Scale measurement 1 YC_BS1, Brain Scale measurement t0, BrainScale age 9
Short description of the wave	The YC_BS1 project was the first measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS1 targeted 9-year old twins (mean age = 9.1 years, SD = 0.51 years) born between 1995 and 1996, and their 9-14 year old siblings (mean age = 11.9 years, SD = 1.16 years) born between 1990 and 1997. The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels (cortisol, luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogens) were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future candidate gene and genome-wide analysis studies.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	051.02.060 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI 051.02.061 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI 56-464-14192 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Spinoza Prize Funder award URI
References	van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378. van Leeuwen, M. (2008). A study of cognition in pre-adolescent twins. https://research.vu.nl/en/publications/a-study-of-cognition-in-pre-adolescent-twins. ISBN: 978 90 9023637 7. Peper, J. S. (2008). The early pubertal brain: work in progress: A study on genetic and hormonal influences. https://research.vu.nl/en/publications/the-early-pubertal-brain-work-in-progress-a-study-on-genetic-and-. ISBN: 978-90-393-4917-5.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2005-01-01
End date wave collection	2005-01-01
Wave universe description	9.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	van Leeuwen, Marieke Vrije Universiteit Amsterdam Peper, Jiska Vrije Universiteit Amsterdam

YC_BS2 Wave

Wave alternate title	Brain Scale measurement 2 YC_BS2, Brain Scale measurement t1, BrainScale age 12
Short description of the wave	The YC_BS2 project was the second measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS2 took place three years after the baseline (YC_BS1) and targeted 12-year old twins (mean age = 12.2 years, SD = 0.3 years) born between 1995 and 1996 and their 9-18 year old siblings (mean age = 14.8 years, SD = 1.3 years) born between 1990 and 1997. The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels (cortisol, luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogens) were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future candidate gene and genome-wide analysis studies.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	56-464-14192 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Spinoza Prize Funder award URI
References	van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378. van Soelen, I. L. C. (2011). Genetics of Structural Brain Development and Cognition in Childhood and Early Adolescence. https://research.vu.nl/en/publications/genetics-of-structural-brain-development-and-cognition-in-childho. ISBN: 978-90-6464-498-6.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2007-01-01
End date wave collection	2009-01-01
Wave universe description	12.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	van Soelen, Inge Vrije Universiteit Amsterdam

YC_BS3 Wave

Wave alternate title	Brain Scale measurement 3 YC_BS3, Brain Scale measurement t2, BrainScale age 17
Short description of the wave	The YC_BS3 project was the third measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS3 took place eight years after the baseline (YC_BS1) and targeted 17-year old twins (mean age = 16.85 years, SD = 0.36 years) born between 1995 and 1996 and their 17-22 old siblings (mean age = 19.26 years, SD = 1.30 years) born between 1990 and 1997..... The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future genetic association studies.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	433-09-220 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
References	van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378. Swagerman, S. C. (2016). Cognitive performance across the lifespan and domains. Koenis, M. M. G. (2017). Adolescent brain development - A longitudinal twin study into structural brain development and its relation to hormone levels and intelligence. https://research.vu.nl/en/publications/adolescent-brain-development-a-longitudinal-study-into-structural. ISBN: 978-94-6299-623-6.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2012-01-01
End date wave collection	2014-01-01
Wave universe description	17.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Swagerman, Suzanne Vrije Universiteit Amsterdam Koenis, Marinka Utrecht University

YC_DSC Wave

Wave alternate title	DISC-IV DSM diagnosis of ADHD and multi-informant CBCL-AP syndrome scores YC_DSC
Short description of the wave	The purpose of the YC_DSC project was to investigate the relation between Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of ADHD and Child Behavioral Checklist Attention Problems (CBCL-AP) scores. Twins were selected based on their maternal CBCL-AP scores at ages 7, 10 and 12 (mean age = 11.7 years, SD = 0.78 years). Twin pairs were selected if at least one of the twins scored high on AP (affected pairs), or if both twins scored low on AP (control pairs). In families that agreed to participate, the mother of the twins was interviewed by telephone with the Diagnostic Interview Schedule for Children (DISC-IV). Other surveys that were collected are the CBCL, SWAN and YSR. Mouth swabs were used to collect buccal cell samples, from which DNA was extracted.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	MH58799-03 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Investigator Initiated Research Grant (R01) Funder award URI
References	Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF, Boomsma DI. The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. Compr Psychiatry. 2006 Mar-Apr;47(2):116-22. doi: 10.1016/j.comppsych.2005.05.006. PMID: 16490569. Derks, E. M. (2006). Assessment and genetic aetiology of attention problems, hyperactivity, and related disorders. Derks EM, Hudziak JJ, Dolan CV, van Beijsterveldt TC, Verhulst FC, Boomsma DI. Genetic and environmental influences on the relation between attention problems and attention deficit hyperactivity disorder. Behav Genet. 2008 Jan;38(1):11-23. doi: 10.1007/s10519-007-9178-8. Epub 2007 Dec 12. PMID: 18074222; PMCID: PMC2226020.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2002-01-01
End date wave collection	2005-01-01
Wave universe description	10.0 - 13.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Derks, Eske M. Vrije Universiteit Amsterdam

YE_FITNSS Wave

Wave alternate title	Determinants of adolescent exercise behavior - the psychological response to exercise YE_FITNSS
Short description of the wave	The YE_FITNSS project aimed to investigate determinants of adolescent exercise behavior in a sample of healthy 16-18 year old twins born between 1993 and 1999 (mean age = 17.1 years, SD = .67 years) and their 12-25 year old siblings born between 1988 and 2000 (mean age = 17.2 years, SD = 3.24 years). Body composition was measured, as well as physical fitness (standing jump, hand grip, sit-and reach flexibility, balance tests). Impulsiveness of the subjects was assessed by the delay discounting questionnaire. Regular voluntary exercise behavior was measured by a short lifestyle interview. While being equipped with a VU University Ambulatory Monitoring System (VU-AMS) and Cosmed device, the subjects performed two submaximal exercise tests and one maximal exercise test. The VU-AMS device records electrocardiogram (ECG) data and impedance cardiogram (ICG) data. The Cosmed device measures oxygen consumption (VO2) and carbon dioxide production (VCO2). VO2max (endurance capacity) was derived during the maximal exercise test. Before, during and after the exercise tests, subjects filled out the Activation-Deactivation Adjective Checklist (AD ACL), Feeling Scale (FS) and the Borg’s Rating of Perceived Exertion (RPE) at multiple time points. These questionnaires determined the subjects’ affective response to exercise. DNA was collected through buccal swabs to determine zygosity.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	de Geus, Eco J. C. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	1R01DK092127-01 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI RO1DK-092127 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI 022.003.010 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
References	Schutte, N. M. (2017). Unraveling the genetic components of voluntary exercise behavior in adolescents and young adults. https://research.vu.nl/en/publications/unraveling-the-genetic-components-of-voluntary-exercise-behavior-. ISBN: 9789463322126.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2012-01-01
End date wave collection	2014-01-01
Wave universe description	16.0 - 18.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Schutte, Nienke M. Vrije Universiteit Amsterdam Nederend, Ineke Vrije Universiteit Amsterdam

YE_ATTEF1 Wave

Wave alternate title	Genetics of attention and executive functioning measurement 1 YE_ATTEF1
Short description of the wave	The YE_ATTEF1 project aimed to examine the etiology of individual differences on attention problems, attention, executive functioning and cognition in 5 to 6-year old twins (mean age = 5.8 years, SD = 0.1 years). This project includes the first measurement of a longitudinal study on the source of individual differences in attention, executive functioning, and cognition in children. Behavioral data was collected with parental and teacher surveys (Aandachtstekort Stoornis met Hyperactiviteit (ASH), Teacher Report Form (TRF), Conners’ Rating Scale, and Devereux Child Behavior Rating Scale (DCB)). Neurocognitive data was collected with computerized tasks (ANT), IQ was assessed with the Revised Amsterdam Child Intelligence Test (RAKIT) and DNA samples were collected by buccal swabs.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	28-2523 Funder identifier Identifier type URI Funder award title Determinanten Aandacht Funder award URI
References	Polderman, T. J. C. (2007). Genetics of Attention and Executive Functioning. https://research.vu.nl/en/publications/genetics-of-attention-and-executive-functioning. ISBN: 9789086590964.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1995-01-01
End date wave collection	1996-01-01
Wave universe description	5.0 - 6.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	de Sonneville, Leo M.J. Vrije Universiteit Amsterdam

YE_ATTEF2 Wave

Wave alternate title	Genetics of attention and executive functioning measurement 2 YE_ATTEF2
Short description of the wave	The YE_ATTEF2 project was the second measurement of a longitudinal study on the source of individual differences of cognition, attention, and executive functioning from preschool to young adulthood. This project included the measurement five years after baseline (YE_ATTEF1) among 12-year old twin pairs (mean age = 12.4 years, SD = 0.14 years) and their 8-16 year old siblings (mean age = 11.97 years, SD = 2.55 years), and additionally recruited new twin pairs and siblings of the twin pairs. Behavioral data were collected with surveys filled in by parents and teachers (Conners, Child Behavior Checklist (CBCL), Strengths and Weaknesses of ADHD symptoms and Normal behavior Scale (SWAN), Teacher Report Form (TRF)) or filled in by children themselves (Youth Self Report (YSR)). To measure pubertal development, children filled in the Tanner questionnaire. Neurocognitive abilities were assessed with computerized ANT tasks, Flanker, Simon and Stroop. IQ was assessed with WISC-R. DNA was collected to determine zygosity and for genotyping SNP’S at candidate gene loci. Saliva was collected to assess cortisol concentrations.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	904-57-94 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
References	Polderman, T. J. C. (2007). Genetics of Attention and Executive Functioning. https://research.vu.nl/en/publications/genetics-of-attention-and-executive-functioning. ISBN: 9789086590964.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2002-01-01
End date wave collection	2004-01-01
Wave universe description	12.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Polderman, Tinca Vrije Universiteit Amsterdam

YE_ATTEF3 Wave

Wave alternate title	Genetics of attention and executive functioning measurement 3 YE_ATTEF3
Short description of the wave	The YE_ATTEF3 project was the third measurement of a longitudinal twin study on attention and cognition. This project included the measurement eleven years after baseline (YE_ATTEF1) and particularly focused on performance pressure. Twins that participated in the previous projects as preschoolers or preteens, were invited again, but additional twin pairs were recruited into the project (ages ranged between 15 and 23 years old, mean age = 18 years, SD = 1.48 years). Cognitive abilities were measured with computerized tests which took place at the VU: a working memory capacity task, a mental rotation task (MRT) and the Advanced Raven’s Progressive Matrices, which measures intelligence. During the Raven and MRT, participants were subjected to either high pressure or low pressure from the test assistants. During the assessment tasks heart rate, cardiac sympathetic and parasympathetic control were measured using the Ambulatory Monitoring System (AMS) device. The tasks were followed by questionnaires about task perception and social comparison.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2007-01-01
End date wave collection	2010-01-01
Wave universe description	15.0 - 23.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Polderman, Tinca Vrije Universiteit Amsterdam

YC_ADHMRI Wave

Wave alternate title	MRI-based research into problem behaviors in twins YC_ADHMRI
Short description of the wave	In the ADHD-MRI project, the genetic and environmental influence on ADHD related neurobiological changes were investigated in monozygotic twins (mean age = 14.9 years, SD = 1.2 years) who were born between 1986 and 1993. Twins were selected based on their Child Behavior Checklist Attention Problems (CBCL-AP) scores obtained in the regular YNTR survey waves and divided into three groups: discordant pairs (one affected, one unaffected), concordant pairs (both affected) and control pairs (both unaffected). To determine the presence of ADHD, mothers of the participants were interviewed with the Diagnostic Interview Schedule for Children (DISC-IV). Additionally, they filled in two behavioral questionnaires (CBCL and Strengths and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN)). The twins filled in the Youth Self Report (YSR). Based on the outcome of the interview and questionnaires, twin pairs that were found eligible for the MRI experiments were invited. Both structural and functional MRI (color-stroop and flanker tasks) were performed. DNA was collected to confirm zygosity.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	MH58799-03 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Investigator Initiated Research Grant (R01) Funder award URI
References	Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF, Boomsma DI. The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. Compr Psychiatry. 2006 Mar-Apr;47(2):116-22. doi: 10.1016/j.comppsych.2005.05.006. PMID: 16490569. Derks, E. M. (2006). Assessment and genetic aetiology of attention problems, hyperactivity, and related disorders. van 't Ent D, Lehn H, Derks EM, Hudziak JJ, Van Strien NM, Veltman DJ, De Geus EJ, Todd RD, Boomsma DI. A structural MRI study in monozygotic twins concordant or discordant for attention/hyperactivity problems: evidence for genetic and environmental heterogeneity in the developing brain. Neuroimage. 2007 Apr 15;35(3):1004-20. doi: 10.1016/j.neuroimage.2007.01.037. Epub 2007 Feb 8. PMID: 17346990; PMCID: PMC1939804. van 't Ent D, van Beijsterveldt CE, Derks EM, Hudziak JJ, Veltman DJ, Todd RD, Boomsma DI, De Geus EJ. Neuroimaging of response interference in twins concordant or discordant for inattention and hyperactivity symptoms. Neuroscience. 2009 Nov 24;164(1):16-29. doi: 10.1016/j.neuroscience.2009.01.056. Epub 2009 Feb 3. PMID: 19409224; PMCID: PMC2760677.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2003-01-01
End date wave collection	2007-01-01
Wave universe description	15.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Derks, Eske M. Vrije Universiteit Amsterdam

YE_COG18 Wave

Wave alternate title	Cognitive abilities of 18-year-old twins YE_COG18
Short description of the wave	The YE_COG18 project is the fifth measurement of a longitudinal study into the development of intelligence and problem behaviour (waves one and two not included in this catalogue, wave 3: YE_COG10, wave 4: YE_COG12), to which additional participants were recruited (twins with siblings and their parents). It targeted 18-year old twins (mean age = 18.1 years, SD = 0.5 years) born between 1986 and 1991, their 8-35 year old siblings (mean age = 18.8 years, SD = 4.9 years) born between 1970 and 1998, and their parents (mean age = 48.9 years, SD = 4.14 years) born between 1942 and 1965. The test protocol consisted of a physical part and a psychological part. Physical measurements included cardiovascular functioning (assessed with the VU-AMS device), a physical examination with basic anthropometric measurements and the collection of saliva, DNA and fingerprints. The psychological part consisted of a series of cognitive tests that measured the following abilities: intelligence (Wechsler Intelligence Scale for Children, WISC-R or Revised Amsterdamse Kinder Intelligentie Test, RAKIT); inhibition (Stroop); spontaneous production of words (Verbal fluency); verbal learning and memory (California Verbal Learning Task, CVLT); emotion recognition (Reading the mind in the eyes); perceptual speed (Π inspection time task); spatial short term memory (n-back task and Corsi block tapping task). Furthermore, some questionnaires were administered to the participants (Autism-Spectrum Quotient, Tanner self-report), mothers of the twins (Social Responsiveness Scale) and research assistants (Test Observation form).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	56-464-14192 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Spinoza Prize Funder award URI
References	Hoekstra, R. A. (2007). Autistic traits, withdrawn behaviour and cognition: a longitudinal twin study from early childhood to young adulthood. https://research.vu.nl/en/publications/autistic-traits-withdrawn-behaviour-and-cognition-a-longitudinal-. Estourgie-van Burk, G. F. (2011). Variation in growth and the influence of early growth in later life: a twin-sibling study. https://research.vu.nl/en/publications/variation-in-growth-and-the-influence-of-early-growth-in-later-li. ISBN: 9789086595532.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2004-01-01
End date wave collection	2006-01-01
Wave universe description	18.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hoekstra, Rosa A. Vrije Universiteit Amsterdam Estourgie-van Burk, Frederiek Vrije Universiteit Amsterdam

YS_TRIP age 1-2 Wave

Wave alternate title	Triplet survey age 1-2 YS_TRIP
Short description of the wave	In 2008, a combination of the triplet surveys at age 1 and 2 was sent to mothers of all triplets in both YNTR and ANTR. The survey was sent to 535 mothers and was returned by 264 mothers (triplet ages ranged between 2 and 38 years, mean age = 11.9, SD = 7.0). Since 2009, the combined survey 1 and 2 serves as the first survey for newly registered triplets at age 2. The combined survey comprises items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, mode of delivery, breastfeeding, attaining milestones, and growth.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2008-01-01
End date wave collection
Wave universe description	24 months - 38.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 3 Wave

Wave alternate title	Triplet survey age 3 YS_TRIP
Short description of the wave	The Child Behavior Checklist (CBCL1.5-5) is sent to parents of approximately 3-year old triplets (mean age = 3.4 years, SD = 0.33 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1991-01-01
End date wave collection
Wave universe description	36 months
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2020) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 4 Wave

Wave alternate title	Triplet survey age 4 YS_TRIP
Short description of the wave	The Child Behavior Checklist was sent to parents of approximately 4-year old triplets born between 1992 and 2005 (mean age = 4.9 years, SD = 0.60 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1998-01-01
End date wave collection	2011-01-01
Wave universe description	4.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 5 Wave

Wave alternate title	Triplet survey age 5 YS_TRIP
Short description of the wave	The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 7-year old triplets (mean age = 7.5 years, SD = 0.75 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1991-01-01
End date wave collection
Wave universe description	5.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 7 Wave

Wave alternate title	Triplet survey age 7 YS_TRIP
Short description of the wave	The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 7-year old triplets (mean age = 7.5 years, SD = 0.75 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1998-01-01
End date wave collection
Wave universe description	7.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 10 Wave

Wave alternate title	Triplet survey age 10 YS_TRIP
Short description of the wave	The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 9 or 10-year old triplets (mean age = 10.1 years, SD = 0.64 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1998-01-01
End date wave collection
Wave universe description	9.0 - 10.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 12 Wave

Wave alternate title	Triplet survey age 12 YS_TRIP
Short description of the wave	The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 12-year old triplets (mean age = 12.2 years, SD = 0.71 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1998-01-01
End date wave collection
Wave universe description	12.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

You can also access this dataset using the API (see API Docs).

author	None
author_email	None
creator_user_id	34768773-4537-4d74-8d9d-11e2b32cbbaf
dc_additional_info	In NTR projects YC_ACTIONBB1_1, YC_ACTIONBB1_2, YC_ACTIONBB2, and YC_ACTIONBB3, YC_BS1, YC_BS2, YC_BS3, YC_DSC, YE_FITNSS, YE_ATTEF1, YE_ATTEF2, YE_ATTEF3, YC_ADHMI, and YE_COG18, as well as in the majority of the YNTR families (collection ongoing outside of mentioned subprojects), DNA is collected by buccal swabs. Zygosity typing was initially based on micro-satellite markers or relatively small numbers of SNPs and is now based on a larger number of SNPs and some repeat polymorphisms in a set of candidate genes. Different sets of SNPs and variable number tandem repeats (VNTRs) in candidate genes have been used over time (see: https://doi.org/10.1017/thg.2012.118). Besides, in NTR projects YS_3, YS_5, YS_7, YS_10, YS_12, YS_TRIP1_2, YS_TRIP3, YS_TRIP4, YS_TRIP5, YS_TRIP7, YS_TRIP10, and YS_TRIP12, parent-reported zygosity confirmation by DNA/blood testing was included in the survey. In NTR projects YC_DSC and YC_ADHMRI, mother-reported zygosity confirmation by DNA/blood testing was included in the telephone interview, and in NTR projects YS_DHBQ14 and YS_DHBW16, self-reported zygosity confirmation by DNA/blood testing was included in the survey as well.
dc_analysis_unit	{Individual}
dc_cohort	NTR
dc_common_id	0031_CD2
id	197476b7-56bd-4245-b029-0541d464848c
isopen	False
license_title	None
maintainer	None
maintainer_email	None
metadata_created	2024-10-17T12:40:59.666935
metadata_modified	2024-10-20T12:52:56.840846
name	25300754dfcf0974113882b16c70c43d
notes	Zygosity typing based on micro-satellite markers, single nucleotide polymorphisms (SNP), or variable number (short) tandem repeats (VNTRs).
num_resources	0
num_tags	0
organization	{'id': '45b26247-5cc8-4bf1-a214-3efb773faa3a', 'name': 'ntr', 'title': 'Netherlands Twin Register', 'type': 'organization', 'description': 'The Netherlands Twin Register (NTR) consists of individuals who have agreed to participate in twin-family studies and was established and is managed by the Department of Biological Psychology, VU University Amsterdam (see: https://tweelingenregister.vu.nl/). The NTR was established in 1987 and has enrolled around 120.000 twins and a roughly equal number of their relatives. The majority of twin families have participated one or more times in survey studies on a host of epidemiological variables including social demography, personality, lifestyle, somatic and mental health, and subsamples took part in biomaterial collection (e.g. DNA) and dedicated projects for e.g. neuropsychological, biomarker, and behavioral traits. The recruitment into the NTR is fully inclusive without any restrictions on enrolment. The NTR is committed to actively seek the commitment of its participants to science and their continued involvement in NTR research by maintaining a website, electronic newsletters, and the MijnNTR portal that provides personalized feedback to participants. The NTR resources, e.g. the longitudinal phenotyping, the extended pedigree structures, and the multi-generation genotyping allow for future twin-family research that will contribute to gene discovery, causality modelling, and studies of genetic and cultural inheritance of behavioral traits and mental and physical health. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR).', 'image_url': 'https://data.individualdevelopment.nl/img/logo_ntr.png', 'created': '2024-10-17T13:43:56.356410', 'is_organization': True, 'approval_status': 'approved', 'state': 'active'}
owner_org	45b26247-5cc8-4bf1-a214-3efb773faa3a
private	False
state	active
title	Zygosity (DNA)
type	measure
cohort	[{'cohort_alternate_title': 'YNTR', 'cohort_description': 'The Young Netherlands Twin Register (YNTR) consists of projects within the Netherlands Twin Register (NTR) that involve families with twins or other multiples under the age of 18.', 'cohort_language': 'NL', 'cohort_purpose': 'The purpose of the projects within the Young Netherlands Twin Register focus on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.', 'cohort_spatial_country_code': 'NL', 'cohort_spatial_highest_reference': 'country', 'cohort_spatial_lowest_reference': 'postal code', 'cohort_time_method': 'Longitudinal.CohortEventBased', 'cohort_title': 'NTR: Young Netherlands Twin Register', 'cohort_universe': 'Families with twins or other multiples under the age of 18.', 'cohort_contributor': [{'cohort_contributor': 'YNTR administration', 'cohort_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'cohort_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'cohort_contributor_affiliation_identifier_scheme': 'ROR', 'cohort_contributor_affiliation_identifier_schemeuri': 'https://ror.org/'}], 'cohort_creator': [{'cohort_creator_affiliation': 'Vrije Universiteit Amsterdam', 'cohort_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Boomsma, Dorret I.', 'cohort_creator_pid': '0000-0002-7099-7972'}], 'cohort_funding': [{'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '480-15-001/674'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '575-25-006'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '480-04-004'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '911-09-032'}], 'cohort_publisher': [{'cohort_publisher_identifier': 'https://ror.org/008xxew50', 'cohort_publisher_identifier_type': 'ROR', 'cohort_publisher_name': 'Vrije Universiteit Amsterdam'}], 'cohort_references': [{'cohort_reference_citation': 'Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420.', 'cohort_reference_identifier': 'https://doi.org/10.1375/183242706779462426', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'cohort_reference_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620.', 'cohort_reference_identifier': 'https://doi.org/10.1017/thg.2012.118', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': "Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.", 'cohort_reference_identifier': 'https://doi.org/10.1017/thg.2019.93', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}]}]
dc_DOI	[{'dc_identifier_type': 'DOI', 'dc_pid': '10.60641/vmwe-td04'}]
dc_constructs	[{'dc_construct': 'physiology'}]
dc_labels	[{'dc_label': 'dna'}, {'dc_label': 'zygosity'}, {'dc_label': 'monozygosity'}, {'dc_label': 'dizygosity'}, {'dc_label': 'buccal sample'}, {'dc_label': 'genetics'}, {'dc_label': 'physical similarity'}, {'dc_label': 'twinning'}]
dc_measurement_references	[{'dc_measurements_references_citation': 'van Beijsterveldt, C. E. M., Groen-Blokhuis, M., Hottenga, J. J., Franić, S., Hudziak, J. J., Lamb, D., Huppertz, C., de Zeeuw, E., Nivard, M., Schutte, N., Swagerman, S., Glasner, T., van Fulpen, M., Brouwer, C., Stroet, T., Nowotny, D., Ehli, E. A., Davies, G. E., Scheet, P., … Boomsma, D. I. (2012). The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. Twin Research and Human Genetics, 16(1), 252–267. https://doi.org/10.1017/thg.2012.118\n', 'dc_measurements_references_doi': 'https://doi.org/10.1017/thg.2012.118'}]
dc_modes_of_collection	[{'dc_mode_of_collection': 'MeasurementsAndTests'}]
dc_modes_of_collection_sub	[{'dc_mode_of_collection_sub': 'Biological sample/measurement'}]
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study	[{'study_alternate_title': 'NTR', 'study_language': 'NL', 'study_purpose': 'The research carried out by the Netherlands Twin Register focuses on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.', 'study_time_method': 'Longitudinal', 'study_universe': 'The recruitment into the NTR is fully inclusive without any restrictions on enrolment. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR). ', 'title': 'Netherlands Twin Register', 'study_contact': [{'study_contact_affiliation': 'Vrije Universiteit Amsterdam', 'study_contact_mail': 'ntr.datamanagement.fgb@vu.nl', 'study_contact_name': 'NTR Data Management'}], 'study_contributor': [{'study_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'study_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'study_contributor_affiliation_identifier_scheme': 'ROR', 'study_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_contributor_name': 'YNTR administration'}], 'study_data_access': [{'study_data_access_URL': 'https://ntr-data-request.psy.vu.nl/', 'study_data_access_description': 'Researchers with an approved data sharing request who abide by the rules of the European General Data Protection Regulation can receive temporary access to the NTR data for their own research projects.'}], 'study_funding': [{'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '480-15-001/674'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '575-25-006'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '480-04-004'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '911-09-032'}], 'study_principal_investigators': [{'study_pi_affiliation': 'Vrije Universiteit Amsterdam', 'study_pi_affiliation_identifier': 'https://ror.org/008xxew50', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Boomsma, Dorret I.', 'study_pi_pid': '0000-0002-7099-7972'}], 'study_publisher': [{'study_publisher_identifier': 'https://ror.org/008xxew50', 'study_publisher_identifier_schemeuri': 'https://ror.org/', 'study_publisher_identifier_type': 'ROR', 'study_publisher_name': 'Vrije Universiteit Amsterdam'}], 'study_references': [{'study_reference_citation': 'Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420.', 'study_reference_identifier': 'https://doi.org/10.1375/183242706779462426', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'study_reference_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620.', 'study_reference_identifier': 'https://doi.org/10.1017/thg.2012.118', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': "Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.", 'study_reference_identifier': 'https://doi.org/10.1017/thg.2019.93', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Bartels M, van Beijsterveldt CE, Derks EM, Stroet TM, Polderman TJ, Hudziak JJ, Boomsma DI. Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. Twin Res Hum Genet. 2007 Feb;10(1):3-11. doi: 10.1375/twin.10.1.3.PMID: 17539360.', 'study_reference_identifier': 'https://doi.org/10.1375/twin.10.1.3', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Boomsma DI, Orlebeke JF, van Baal GC.Behav Genet. The Dutch Twin Register: growth data on weight and height. 1992 Mar;22(2):247-51. doi: 10.1007/BF01067004', 'study_reference_identifier': 'https://doi.org/10.1007/BF01067004', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Franić S, Dolan CV, van Beijsterveldt CE, Hulshoff Pol HE, Bartels M, Boomsma DI. Genetic and environmental stability of intelligence in childhood and adolescence. Twin Res Hum Genet. 2014 Jun;17(3):151-63. doi: 10.1017/thg.2014.', 'study_reference_identifier': 'https://doi.org/10.1017/thg.2014', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}]}]
wave	[{'wave_alternate_title': 'YNTR survey age 3 [YS_3]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YS_3 survey is sent to both parents around the 3rd birth year of the twins (mean age = 3.35 years, SD = 0.275 years). The survey includes the CBCL 1.5-5, items on zygosity, health, growth data as obtained from the Dutch National Health Services, child care, demographic characteristics, including religious background and parental education and occupation. From 2009 onwards, additional items on well-being, leisure activities, sport activities and life events of the parents are included.', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2016) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1990-01-01', 'wave_title': 'YS_3', 'wave_universe': '36', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_grant_number': '165'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': "van der Valk, J. C. (2001). The Genetic and Environmental Contributions to Children's Problem Behaviors: A Developmental Approach. https://research.vu.nl/en/publications/the-genetic-and-environmental-contributions-to-childrens-problem-. ISBN: 90-9014842-6.", 'wave_references_identifier': 'https://hdl.handle.net/1871.1/fa5d1334-9353-476a-aca6-8c2d5a33e8eb', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'YNTR survey age 5 [YS_5]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YS_5 survey is sent to the mothers around the 5th birth year of the twins (mean age = 5.52 years, SD = 0.55 years). The survey includes items on child care and school, growth, zygosity, toilet training, asthma and eczema, fine motor coordination, language development, and problem behaviors as assessed by a short version of the Devereux Child Behavior Checklist (DCB). The booklet includes an extra section for fathers of twins to report about behavior problems. From 2011 onward, items on child care and school, living and family situation were updated and items on wellbeing were added. From the second half of 2015 the short form of the Childhood Behavior Questionnaire (CBQ) was added. From 2017 the surveys no longer have a separate section for the father.', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data are digitally archived. ', 'wave_start_date_collection': '1994-01-01', 'wave_title': 'YS_5', 'wave_universe': '60', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'YNTR survey age 7 [YS_7]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YS_7 survey collects information on the twins at age 7 (mean age = 7.47 years, SD = 0.40 years) from both parents and targets the development of emotional and behavior problems, as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, vaccinations, tonsillectomy (from 2005), demographic characteristics, growth, sport and leisure activity of both children and parents, and additional items on wellbeing (from 2010). In 2017 the survey was considerably shortened (for example the Conners was removed).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1995-01-01', 'wave_title': 'YS_7', 'wave_universe': '84', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_grant_number': '165'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'wave_references_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': "van der Valk, J. C. (2001). The Genetic and Environmental Contributions to Children's Problem Behaviors: A Developmental Approach. https://research.vu.nl/en/publications/the-genetic-and-environmental-contributions-to-childrens-problem-. ISBN: 90-9014842-6.", 'wave_references_identifier': 'https://hdl.handle.net/1871.1/fa5d1334-9353-476a-aca6-8c2d5a33e8eb', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'YNTR survey age 9/10 [YS_10]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YNTR survey 9/10 targets the development of emotional and behavior problems in 9-10 year old twins (mean age = 9.9 years, SD = 0.52 years), as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, vaccinations, tonsillectomy (from 2005), demographic characteristics, growth, sport and leisure activity of both children and parents, and additional items on wellbeing (from 2010).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1997-01-01', 'wave_title': 'YS_10', 'wave_universe': '108-120', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'wave_references_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'YNTR survey age 12 [YS_12]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': "The YNTR survey 12 was emailed to both parents of twins around the 12th birthday of the twins (mean age = 12.35 years, SD = 0.53 years). The survey targets the development of emotional and behavior problems as assessed by the Child Behavior Checklist 6-18 (CBCL). From 2001 onwards, the Conners’ Parent Rating Scale - Revised (CPRS-R) was also included. In addition, these surveys included items on zygosity, medical conditions, demographic characteristics, growth, sport and leisure activity of both children and parents (from 2003), and additional items on wellbeing (from 2008). In 2017 and 2018 the length of the questionnaire was shortened, the ASEBA Brief Problem Monitor (BPM) was used instead of the CBCL, and the 'cito survey' was added (see YS_CITO). From 2019, the questionnaire returned to its original length with CBCL and Conners items, and from 2020 the items on leisure time and on family and living situation were removed.", 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2017) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1998-01-01', 'wave_title': 'YS_12', 'wave_universe': '144', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Dutch Health and Behavior Questionnaire - age 14 [YS_DHBQ14]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Dutch Health and Behavior Questionnaire (DHBQ) was developed at the department of Biological Psychology of the VU University. It is a collection of standardized questions targeting multiple domains. The focus of the survey is on emotional and behavioral problems assessed by the Youth Self-Report (YSR), subjective wellbeing, lifestyle, exercise behavior, sedentary behavior, and family functioning. The YS_DHBQ14 project targeted 14-year old twins or triplets (mean age = 14.6 years, SD = 0.65 years) born between 1989 and 1999 and their 12-25 year old siblings (mean = 17.3 years, SD = 2.55 years) born between 1981 and 2001.', 'wave_end_date_collection': '2013-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2009) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2005-01-01', 'wave_title': 'YS_DHBQ14', 'wave_universe': '168', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': '', 'wave_contributor_identifier_type': '', 'wave_contributor_name': 'YNTR administration', 'wave_contributor_pid': ''}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'van der Aa, Niels', 'wave_contributor_pid': '0000-0003-1366-4001'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Huppertz, Charlotte', 'wave_contributor_pid': '0000-0002-5699-2518'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '463-06-001'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'van der Aa, N. (2011). Causes of variation in adolescent wellbeing. https://research.vu.nl/en/publications/causes-of-variation-in-adolescent-wellbeing. ISBN: 978-94-6169-009-8.', 'wave_references_identifier': 'https://hdl.handle.net/1871/18574', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Huppertz, C. (2016). How voluntary exercise behavior runs in families: Twin studies and beyond. https://research.vu.nl/en/publications/how-voluntary-exercise-behavior-runs-in-families-twin-studies-and. ISBN: 978-94-6299-314-3.', 'wave_references_identifier': 'https://hdl.handle.net/1871/54304', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'CC', 'wave_subject_code_translated': 'Child on self'}]}, {'wave_alternate_title': 'Dutch Health and Behavior Questionnaire - age 16 [YS_DHBQ16]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Dutch Health and Behavior Questionnaire (DHBQ) was developed at the department of Biological Psychology of the VU University. It is a collection of standardized questions targeting multiple domains. The focus of the survey is on emotional and behavioral problems assessed by the Youth Self-Report (YSR), subjective wellbeing, lifestyle, exercise behavior, sedentary behavior, and family functioning. From 2007, the survey includes the NEO Five Factor Inventory (NEO-FFI) and removed items regarding religion, stuttering, type of transportation to school, and hair/eye color. The YS_DHBQ16 project targeted 16-year old twins or triplets (mean age = 16.9 years, SD = 0.55 years) born between 1987 and 1999 and their 12-25 year old siblings (mean age = 18.5 years, SD = 3.34 years) born between 1981 and 2000.', 'wave_end_date_collection': '2013-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2009) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2005-01-01', 'wave_title': 'YS_DHBQ16', 'wave_universe': '192', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': '', 'wave_contributor_identifier_type': '', 'wave_contributor_name': 'YNTR administration', 'wave_contributor_pid': ''}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'van der Aa, Niels', 'wave_contributor_pid': '0000-0003-1366-4001'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Huppertz, Charlotte', 'wave_contributor_pid': '0000-0002-5699-2518'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '463-06-001'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'van der Aa, N. (2011). Causes of variation in adolescent wellbeing. https://research.vu.nl/en/publications/causes-of-variation-in-adolescent-wellbeing. ISBN: 978-94-6169-009-8.', 'wave_references_identifier': 'https://hdl.handle.net/1871/18574', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Huppertz, C. (2016). How voluntary exercise behavior runs in families: Twin studies and beyond. https://research.vu.nl/en/publications/how-voluntary-exercise-behavior-runs-in-families-twin-studies-and. ISBN: 978-94-6299-314-3.', 'wave_references_identifier': 'https://hdl.handle.net/1871/54304', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'CC', 'wave_subject_code_translated': 'Child on self'}]}, {'wave_alternate_title': 'Wave 1 Technical Pilot ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The first wave of the technical pilot of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the technical pilot was to test the collection protocols for urine and buccal sample collection in 10-13 year old twins (mean age = 11.6 years, SD = 0.9 years) born between 2002 and 2005. The technical pilot comprised of twin participants with a low aggression score (T-score<65) on the mother-reported ASEBA CBCL Aggression Syndrome Scale at age 3 and/or age 7. Urine samples with minimal information regarding urine collection were collected at two timepoints with an interval of approximately two weeks. Urine samples contributed to the optimization of the biomarker assays and the liquid and gas chromatography mass spectrometry protocols for analyzing urine samples in children. In the technical pilot a urine dipstick and assessment of urine density (specific gravity) were obtained in addition to 15 biomarker assays (creatinine, neopterin, C-peptide, Substance P, Oxidized DNA/RNA, Procalcitonin, total antioxidant capacity, glucose, Thiobarbituric acid reactive species, beta-endorphin, cholecytokin, leu-enkaphalin, dynorphin A, albumin, and neurotensin) , and two metabolomics platforms (liquid chromatography mass spectrometry platform targeting amines and gas chromatography mass spectrometry platform targeting organic acids). Buccal-cell samples were also collected at both time points where samples obtained from wave 1 were genotyped on the Affymetrix Axiom genotyping array. ', 'wave_end_date_collection': '2015-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2014-01-01', 'wave_title': 'YC_ACTION BB1_1', 'wave_universe': '120-156', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Wave 2 Technical Pilot ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The second wave of the technical pilot of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the technical pilot was to test the collection protocols for urine and buccal sample collection in 10-13 year old twins born between 2002 and 2005 (mean age = 11.6 years, SD = 0.9 years). The technical pilot comprised twin participants with a low aggression score (T-score<65) on the mother-reported ASEBA CBCL Aggression Syndrome Scale at age 3 and/or age 7. Urine samples with minimal information regarding urine collection were collected at two timepoints with an interval of approximately two weeks. Urine samples contributed to the optimization of the biomarker assays and the liquid and gas chromatography mass spectrometry protocols for analyzing urine samples in children. In the technical pilot a urine dipstick and assessment of urine density (specific gravity) were obtained in addition to 15 biomarker assays (creatinine, neopterin, C-peptide, Substance P, Oxidized DNA/RNA, Procalcitonin, total antioxidant capacity, glucose, Thiobarbituric acid reactive species, beta-endorphin, cholecytokin, leu-enkaphalin, dynorphin A, albumin, and neurotensin), and two metabolomics platforms (liquid chromatography mass spectrometry platform targeting amines and gas chromatography mass spectrometry platform targeting organic acids). Buccal-cell samples were also collected at both time points where samples obtained from wave 1 were genotyped on the Affymetrix Axiom genotyping array.', 'wave_end_date_collection': '2015-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2014-01-01', 'wave_title': 'YC_ACTION BB1_2', 'wave_universe': '120-156', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Biochemical Study ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The biochemical study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the biochemical study was to further validate the biomarker assays and metabolomics platforms selected during the two waves of the technical pilot (YC_ACTION BB1_1 BB1_2) in a larger sample of 6-11 year old twins born between 2004 and 2009 (mean age = 9.9 years, SD = 1.6 years). The twins were selected based on their mother-rated aggression scores (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist) at age 3 and/or 7. The Biochemical study comprised concordant low-scoring twin pairs, concordant high-scoring twin pairs, and a discordant low-high scoring twin pairs. High aggression was defined as having an ASEBA CBCL Aggression Syndrome Scale T-score equal to or larger than 65, and low aggression as an ASEBA CBCL Aggression Syndrome Scale T-score of less than 65. Here, data collection comprised of first-morning urine samples and buccal-cell DNA samples in the twins and family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, oxidized DNA/RNA, procalcitonin, total antioxidant capacity, and glucose, and two metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; and 2) a LC-MS platform targeting steroid hormones. Buccal-cell samples were genotyped on the Affymetrix Axiom genotyping array. ', 'wave_end_date_collection': '2015-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2015-01-01', 'wave_title': 'YC_ACTION BB2', 'wave_universe': '72-132', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Main Study ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Main Study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu), after the technical pilots (YC_ACTION BB1_1 and BB1_2) and the Biochemical study (YC_ACTION BB2). Here, data collection of first-morning urine samples for metabolomics biomarker discovery and buccal-cell DNA samples for (epi)genetics was conducted in a large cohort of 6-13 year old twins born between 2004 and 2011 (mean age = 9.5 years, SD = 1.9 years). Family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. The twins were selected to be part of a concordant low-scoring twin pair, a concordant high-scoring twin pair, or a discordant twin pair. Aggression had been assessed in the past by the age-appropriate version of the CBCL (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist). During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, and oxidized DNA/RNA. Metabolomics data of the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were were obtained from three metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; 2) a LC-MS platform targeting steroid hormones; and 3) a gas chromatography (GC) MS platform targeting organic acids. Buccal-cell samples of the twins from the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were used for genome-wide methylation measurement on the Infinium MethylationEPIC BeadChip Kit (after conclussion of the ACTION project additional twin pairs and siblings were also measured on this platform). DNA samples from all family members were genotyped on the Affymetrix Axiom or Illumina GSA genotyping arrays.', 'wave_end_date_collection': '2017-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2016-01-01', 'wave_title': 'YC_ACTION - BB3', 'wave_universe': '72-156', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': ['Brain Scale measurement 1 [YC_BS1]', 'Brain Scale measurement t0', 'BrainScale age 9'], 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YC_BS1 project was the first measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS1 targeted 9-year old twins (mean age = 9.1 years, SD = 0.51 years) born between 1995 and 1996, and their 9-14 year old siblings (mean age = 11.9 years, SD = 1.16 years) born between 1990 and 1997. The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels (cortisol, luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogens) were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future candidate gene and genome-wide analysis studies.', 'wave_end_date_collection': '2005-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2005-01-01', 'wave_title': 'YC_BS1', 'wave_universe': '108', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'van Leeuwen, Marieke', 'wave_contributor_pid': '0000-0003-1976-5831'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'Peper, Jiska'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': '', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '051.02.060'}, {'wave_funder_award_title': '', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '051.02.061'}, {'wave_funder_award_title': 'Spinoza Prize', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '56-464-14192'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378.', 'wave_references_identifier': 'https://doi.org/10.1017/thg.2012.4', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'van Leeuwen, M. (2008). A study of cognition in pre-adolescent twins. https://research.vu.nl/en/publications/a-study-of-cognition-in-pre-adolescent-twins. ISBN: 978 90 9023637 7.', 'wave_references_identifier': 'https://hdl.handle.net/1871/13072', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Peper, J. S. (2008). The early pubertal brain: work in progress: A study on genetic and hormonal influences. https://research.vu.nl/en/publications/the-early-pubertal-brain-work-in-progress-a-study-on-genetic-and-. ISBN: 978-90-393-4917-5.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/f6c21ff1-e62d-42b3-9baf-137c698b9e71', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': ['Brain Scale measurement 2 [YC_BS2]', 'Brain Scale measurement t1', 'BrainScale age 12'], 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YC_BS2 project was the second measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS2 took place three years after the baseline (YC_BS1) and targeted 12-year old twins (mean age = 12.2 years, SD = 0.3 years) born between 1995 and 1996 and their 9-18 year old siblings (mean age = 14.8 years, SD = 1.3 years) born between 1990 and 1997. The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels (cortisol, luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogens) were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future candidate gene and genome-wide analysis studies.', 'wave_end_date_collection': '2009-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2007-01-01', 'wave_title': 'YC_BS2', 'wave_universe': '144', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'van Soelen, Inge'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Spinoza Prize', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '56-464-14192'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378.', 'wave_references_identifier': 'https://doi.org/10.1017/thg.2012.4', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'van Soelen, I. L. C. (2011). Genetics of Structural Brain Development and Cognition in Childhood and Early Adolescence. https://research.vu.nl/en/publications/genetics-of-structural-brain-development-and-cognition-in-childho. ISBN: 978-90-6464-498-6.', 'wave_references_identifier': 'https://hdl.handle.net/1871/23946', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': ['Brain Scale measurement 3 [YC_BS3]', 'Brain Scale measurement t2', 'BrainScale age 17'], 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YC_BS3 project was the third measurement in the Dutch longitudinal Brain Scale study in which twins, their siblings and their parents were assessed at three year intervals. YC_BS3 took place eight years after the baseline (YC_BS1) and targeted 17-year old twins (mean age = 16.85 years, SD = 0.36 years) born between 1995 and 1996 and their 17-22 old siblings (mean age = 19.26 years, SD = 1.30 years) born between 1990 and 1997..... The main aim of the Brain Scale project was to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition. Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol, and parental and self-ratings of behavioral and emotional problems. Physical maturation was measured through assessment of Tanner stages. Hormonal levels were assessed in urine and saliva. Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness. Buccal swabs were collected for DNA isolation for future genetic association studies.', 'wave_end_date_collection': '2014-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2012-01-01', 'wave_title': 'YC_BS3', 'wave_universe': '204', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': '', 'wave_contributor_identifier_type': '', 'wave_contributor_name': 'Swagerman, Suzanne', 'wave_contributor_pid': ''}, {'wave_contributor_affiliation': 'Utrecht University', 'wave_contributor_affiliation_identifier': 'https://ror.org/04pp8hn57', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Koenis, Marinka', 'wave_contributor_pid': '0000-0002-3859-3847'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '433-09-220'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'van Soelen IL, Brouwer RM, Peper JS, van Leeuwen M, Koenis MM, van Beijsterveldt TC, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: brain structure and cognition: an adolescent longitudinal twin study into the genetic etiology of individual differences. Twin Res Hum Genet. 2012 Jun;15(3):453-67. doi: 10.1017/thg.2012.4. PMID: 22856378.', 'wave_references_identifier': 'https://doi.org/10.1017/thg.2012.4', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Swagerman, S. C. (2016). Cognitive performance across the lifespan and domains.', 'wave_references_identifier': 'https://hdl.handle.net/1871/54246', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Koenis, M. M. G. (2017). Adolescent brain development - A longitudinal twin study into structural brain development and its relation to hormone levels and intelligence. https://research.vu.nl/en/publications/adolescent-brain-development-a-longitudinal-study-into-structural. ISBN: 978-94-6299-623-6.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/4369a1fc-358f-48f4-ba45-2b981d657afc', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'DISC-IV DSM diagnosis of ADHD and multi-informant CBCL-AP syndrome scores [YC_DSC]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The purpose of the YC_DSC project was to investigate the relation between Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of ADHD and Child Behavioral Checklist Attention Problems (CBCL-AP) scores. Twins were selected based on their maternal CBCL-AP scores at ages 7, 10 and 12 (mean age = 11.7 years, SD = 0.78 years). Twin pairs were selected if at least one of the twins scored high on AP (affected pairs), or if both twins scored low on AP (control pairs). In families that agreed to participate, the mother of the twins was interviewed by telephone with the Diagnostic Interview Schedule for Children (DISC-IV). Other surveys that were collected are the CBCL, SWAN and YSR. Mouth swabs were used to collect buccal cell samples, from which DNA was extracted.', 'wave_end_date_collection': '2005-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2002-01-01', 'wave_title': 'YC_DSC', 'wave_universe': '120-156', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Derks, Eske M.', 'wave_contributor_pid': '0000-0002-6292-6883'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Investigator Initiated Research Grant (R01)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': 'MH58799-03'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF, Boomsma DI. The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. Compr Psychiatry. 2006 Mar-Apr;47(2):116-22. doi: 10.1016/j.comppsych.2005.05.006. PMID: 16490569.', 'wave_references_identifier': 'https://doi.org/10.1016/j.comppsych.2005.05.006', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Derks, E. M. (2006). Assessment and genetic aetiology of attention problems, hyperactivity, and related disorders.', 'wave_references_identifier': 'https://hdl.handle.net/1871/10547', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Derks EM, Hudziak JJ, Dolan CV, van Beijsterveldt TC, Verhulst FC, Boomsma DI. Genetic and environmental influences on the relation between attention problems and attention deficit hyperactivity disorder. Behav Genet. 2008 Jan;38(1):11-23. doi: 10.1007/s10519-007-9178-8. Epub 2007 Dec 12. PMID: 18074222; PMCID: PMC2226020.', 'wave_references_identifier': 'https://doi.org/10.1007/s10519-007-9178-8', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Determinants of adolescent exercise behavior - the psychological response to exercise [YE_FITNSS]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_FITNSS project aimed to investigate determinants of adolescent exercise behavior in a sample of healthy 16-18 year old twins born between 1993 and 1999 (mean age = 17.1 years, SD = .67 years) and their 12-25 year old siblings born between 1988 and 2000 (mean age = 17.2 years, SD = 3.24 years). Body composition was measured, as well as physical fitness (standing jump, hand grip, sit-and reach flexibility, balance tests). Impulsiveness of the subjects was assessed by the delay discounting questionnaire. Regular voluntary exercise behavior was measured by a short lifestyle interview. While being equipped with a VU University Ambulatory Monitoring System (VU-AMS) and Cosmed device, the subjects performed two submaximal exercise tests and one maximal exercise test. The VU-AMS device records electrocardiogram (ECG) data and impedance cardiogram (ICG) data. The Cosmed device measures oxygen consumption (VO2) and carbon dioxide production (VCO2). VO2max (endurance capacity) was derived during the maximal exercise test. Before, during and after the exercise tests, subjects filled out the Activation-Deactivation Adjective Checklist (AD ACL), Feeling Scale (FS) and the Borg’s Rating of Perceived Exertion (RPE) at multiple time points. These questionnaires determined the subjects’ affective response to exercise. DNA was collected through buccal swabs to determine zygosity.', 'wave_end_date_collection': '2014-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2012-01-01', 'wave_title': 'YE_FITNSS', 'wave_universe': '192-216', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Schutte, Nienke M.', 'wave_contributor_pid': '0000-0002-8064-2569'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Nederend, Ineke', 'wave_contributor_pid': '0000-0003-1873-9922'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'de Geus, Eco J. C.', 'wave_creator_pid': '0000-0001-6022-2666'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '1R01DK092127-01'}, {'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': 'RO1DK-092127'}, {'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '022.003.010'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Schutte, N. M. (2017). Unraveling the genetic components of voluntary exercise behavior in adolescents and young adults. https://research.vu.nl/en/publications/unraveling-the-genetic-components-of-voluntary-exercise-behavior-. ISBN: 9789463322126.', 'wave_references_identifier': 'https://hdl.handle.net/1871/55350', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Genetics of attention and executive functioning measurement 1 [YE_ATTEF1]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_ATTEF1 project aimed to examine the etiology of individual differences on attention problems, attention, executive functioning and cognition in 5 to 6-year old twins (mean age = 5.8 years, SD = 0.1 years). This project includes the first measurement of a longitudinal study on the source of individual differences in attention, executive functioning, and cognition in children. Behavioral data was collected with parental and teacher surveys (Aandachtstekort Stoornis met Hyperactiviteit (ASH), Teacher Report Form (TRF), Conners’ Rating Scale, and Devereux Child Behavior Rating Scale (DCB)). Neurocognitive data was collected with computerized tasks (ANT), IQ was assessed with the Revised Amsterdam Child Intelligence Test (RAKIT) and DNA samples were collected by buccal swabs.', 'wave_end_date_collection': '1996-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1995-01-01', 'wave_title': 'YE_ATTEF1', 'wave_universe': '60-72', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'de Sonneville, Leo M.J.', 'wave_contributor_pid': '0000-0003-0133-4953'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Determinanten Aandacht', 'wave_grant_number': '28-2523'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Polderman, T. J. C. (2007). Genetics of Attention and Executive Functioning. https://research.vu.nl/en/publications/genetics-of-attention-and-executive-functioning. ISBN: 9789086590964.', 'wave_references_identifier': 'https://hdl.handle.net/1871/10808', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Genetics of attention and executive functioning measurement 2 [YE_ATTEF2]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_ATTEF2 project was the second measurement of a longitudinal study on the source of individual differences of cognition, attention, and executive functioning from preschool to young adulthood. This project included the measurement five years after baseline (YE_ATTEF1) among 12-year old twin pairs (mean age = 12.4 years, SD = 0.14 years) and their 8-16 year old siblings (mean age = 11.97 years, SD = 2.55 years), and additionally recruited new twin pairs and siblings of the twin pairs. Behavioral data were collected with surveys filled in by parents and teachers (Conners, Child Behavior Checklist (CBCL), Strengths and Weaknesses of ADHD symptoms and Normal behavior Scale (SWAN), Teacher Report Form (TRF)) or filled in by children themselves (Youth Self Report (YSR)). To measure pubertal development, children filled in the Tanner questionnaire. Neurocognitive abilities were assessed with computerized ANT tasks, Flanker, Simon and Stroop. IQ was assessed with WISC-R. DNA was collected to determine zygosity and for genotyping SNP’S at candidate gene loci. Saliva was collected to assess cortisol concentrations.', 'wave_end_date_collection': '2004-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2002-01-01', 'wave_title': 'YE_ATTEF2', 'wave_universe': '144', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Polderman, Tinca', 'wave_contributor_pid': '0000-0001-5564-301X'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '904-57-94'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Polderman, T. J. C. (2007). Genetics of Attention and Executive Functioning. https://research.vu.nl/en/publications/genetics-of-attention-and-executive-functioning. ISBN: 9789086590964.', 'wave_references_identifier': 'https://hdl.handle.net/1871/10808', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Genetics of attention and executive functioning measurement 3 [YE_ATTEF3]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_ATTEF3 project was the third measurement of a longitudinal twin study on attention and cognition. This project included the measurement eleven years after baseline (YE_ATTEF1) and particularly focused on performance pressure. Twins that participated in the previous projects as preschoolers or preteens, were invited again, but additional twin pairs were recruited into the project (ages ranged between 15 and 23 years old, mean age = 18 years, SD = 1.48 years). Cognitive abilities were measured with computerized tests which took place at the VU: a working memory capacity task, a mental rotation task (MRT) and the Advanced Raven’s Progressive Matrices, which measures intelligence. During the Raven and MRT, participants were subjected to either high pressure or low pressure from the test assistants. During the assessment tasks heart rate, cardiac sympathetic and parasympathetic control were measured using the Ambulatory Monitoring System (AMS) device. The tasks were followed by questionnaires about task perception and social comparison.', 'wave_end_date_collection': '2010-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2007-01-01', 'wave_title': 'YE_ATTEF3', 'wave_universe': '180-276', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Polderman, Tinca', 'wave_contributor_pid': '0000-0001-5564-301X'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'MRI-based research into problem behaviors in twins [YC_ADHMRI]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'In the ADHD-MRI project, the genetic and environmental influence on ADHD related neurobiological changes were investigated in monozygotic twins (mean age = 14.9 years, SD = 1.2 years) who were born between 1986 and 1993. Twins were selected based on their Child Behavior Checklist Attention Problems (CBCL-AP) scores obtained in the regular YNTR survey waves and divided into three groups: discordant pairs (one affected, one unaffected), concordant pairs (both affected) and control pairs (both unaffected). To determine the presence of ADHD, mothers of the participants were interviewed with the Diagnostic Interview Schedule for Children (DISC-IV). Additionally, they filled in two behavioral questionnaires (CBCL and Strengths and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN)). The twins filled in the Youth Self Report (YSR). Based on the outcome of the interview and questionnaires, twin pairs that were found eligible for the MRI experiments were invited. Both structural and functional MRI (color-stroop and flanker tasks) were performed. DNA was collected to confirm zygosity.', 'wave_end_date_collection': '2007-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2003-01-01', 'wave_title': 'YC_ADHMRI', 'wave_universe': '180', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Derks, Eske M.', 'wave_contributor_pid': '0000-0002-6292-6883'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Investigator Initiated Research Grant (R01)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': 'MH58799-03'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Derks EM, Hudziak JJ, Dolan CV, Ferdinand RF, Boomsma DI. The relations between DISC-IV DSM diagnoses of ADHD and multi-informant CBCL-AP syndrome scores. Compr Psychiatry. 2006 Mar-Apr;47(2):116-22. doi: 10.1016/j.comppsych.2005.05.006. PMID: 16490569.', 'wave_references_identifier': 'https://doi.org/10.1016/j.comppsych.2005.05.006', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Derks, E. M. (2006). Assessment and genetic aetiology of attention problems, hyperactivity, and related disorders.', 'wave_references_identifier': 'https://hdl.handle.net/1871/10547', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': "van 't Ent D, Lehn H, Derks EM, Hudziak JJ, Van Strien NM, Veltman DJ, De Geus EJ, Todd RD, Boomsma DI. A structural MRI study in monozygotic twins concordant or discordant for attention/hyperactivity problems: evidence for genetic and environmental heterogeneity in the developing brain. Neuroimage. 2007 Apr 15;35(3):1004-20. doi: 10.1016/j.neuroimage.2007.01.037. Epub 2007 Feb 8. PMID: 17346990; PMCID: PMC1939804.", 'wave_references_identifier': 'https://doi.org/10.1016/j.neuroimage.2007.01.037', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': "van 't Ent D, van Beijsterveldt CE, Derks EM, Hudziak JJ, Veltman DJ, Todd RD, Boomsma DI, De Geus EJ. Neuroimaging of response interference in twins concordant or discordant for inattention and hyperactivity symptoms. Neuroscience. 2009 Nov 24;164(1):16-29. doi: 10.1016/j.neuroscience.2009.01.056. Epub 2009 Feb 3. PMID: 19409224; PMCID: PMC2760677.", 'wave_references_identifier': 'https://doi.org/10.1016/j.neuroscience.2009.01.056', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Cognitive abilities of 18-year-old twins [YE_COG18]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_COG18 project is the fifth measurement of a longitudinal study into the development of intelligence and problem behaviour (waves one and two not included in this catalogue, wave 3: YE_COG10, wave 4: YE_COG12), to which additional participants were recruited (twins with siblings and their parents). It targeted 18-year old twins (mean age = 18.1 years, SD = 0.5 years) born between 1986 and 1991, their 8-35 year old siblings (mean age = 18.8 years, SD = 4.9 years) born between 1970 and 1998, and their parents (mean age = 48.9 years, SD = 4.14 years) born between 1942 and 1965. The test protocol consisted of a physical part and a psychological part. Physical measurements included cardiovascular functioning (assessed with the VU-AMS device), a physical examination with basic anthropometric measurements and the collection of saliva, DNA and fingerprints. The psychological part consisted of a series of cognitive tests that measured the following abilities: intelligence (Wechsler Intelligence Scale for Children, WISC-R or Revised Amsterdamse Kinder Intelligentie Test, RAKIT); inhibition (Stroop); spontaneous production of words (Verbal fluency); verbal learning and memory (California Verbal Learning Task, CVLT); emotion recognition (Reading the mind in the eyes); perceptual speed (Π inspection time task); spatial short term memory (n-back task and Corsi block tapping task). Furthermore, some questionnaires were administered to the participants (Autism-Spectrum Quotient, Tanner self-report), mothers of the twins (Social Responsiveness Scale) and research assistants (Test Observation form).', 'wave_end_date_collection': '2006-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2004-01-01', 'wave_title': 'YE_COG18', 'wave_universe': '216', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hoekstra, Rosa A.', 'wave_contributor_pid': '0000-0002-1333-9762'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Estourgie-van Burk, Frederiek', 'wave_contributor_pid': '0000-0001-7562-641X'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Spinoza Prize', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '56-464-14192'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Hoekstra, R. A. (2007). Autistic traits, withdrawn behaviour and cognition: a longitudinal twin study from early childhood to young adulthood. https://research.vu.nl/en/publications/autistic-traits-withdrawn-behaviour-and-cognition-a-longitudinal-.', 'wave_references_identifier': 'https://hdl.handle.net/1871/33194', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Estourgie-van Burk, G. F. (2011). Variation in growth and the influence of early growth in later life: a twin-sibling study. https://research.vu.nl/en/publications/variation-in-growth-and-the-influence-of-early-growth-in-later-li. ISBN: 9789086595532.', 'wave_references_identifier': 'https://hdl.handle.net/1871/19635', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'C', 'wave_subject_code_translated': 'Child'}]}, {'wave_alternate_title': 'Triplet survey age 1-2 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'In 2008, a combination of the triplet surveys at age 1 and 2 was sent to mothers of all triplets in both YNTR and ANTR. The survey was sent to 535 mothers and was returned by 264 mothers (triplet ages ranged between 2 and 38 years, mean age = 11.9, SD = 7.0). Since 2009, the combined survey 1 and 2 serves as the first survey for newly registered triplets at age 2. The combined survey comprises items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, mode of delivery, breastfeeding, attaining milestones, and growth.', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2008-01-01', 'wave_title': 'YS_TRIP age 1-2', 'wave_universe': '24-456', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 3 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist (CBCL1.5-5) is sent to parents of approximately 3-year old triplets (mean age = 3.4 years, SD = 0.33 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2020) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1991-01-01', 'wave_title': 'YS_TRIP age 3', 'wave_universe': '36', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 4 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist was sent to parents of approximately 4-year old triplets born between 1992 and 2005 (mean age = 4.9 years, SD = 0.60 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_end_date_collection': '2011-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1998-01-01', 'wave_title': 'YS_TRIP age 4', 'wave_universe': '48', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 5 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 7-year old triplets (mean age = 7.5 years, SD = 0.75 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1991-01-01', 'wave_title': 'YS_TRIP age 5', 'wave_universe': '60', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 7 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 7-year old triplets (mean age = 7.5 years, SD = 0.75 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1998-01-01', 'wave_title': 'YS_TRIP age 7', 'wave_universe': '84', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 10 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 9 or 10-year old triplets (mean age = 10.1 years, SD = 0.64 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1998-01-01', 'wave_title': 'YS_TRIP age 10', 'wave_universe': '108-120', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}, {'wave_alternate_title': 'Triplet survey age 12 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Child Behavior Checklist (CBCL6-18) is sent to parents of approximately 12-year old triplets (mean age = 12.2 years, SD = 0.71 years), together with a short general questionnaire on parental and triplet characteristics (e.g. parental employment and religion, triplet school achievements and health).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1998-01-01', 'wave_title': 'YS_TRIP age 12', 'wave_universe': '144', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MC', 'wave_subject_code_translated': 'Mother (biological or non-biological) on Child'}, {'wave_subject_code': 'FC', 'wave_subject_code_translated': 'Father (biological or non-biological) on Child'}]}]
resources	[]
tags	[]
groups	[]
relationships_as_subject	[]
relationships_as_object	[]
tracking_summary	{'total': 0, 'recent': 0}