Dataset

Supplement use

Nutritional supplement use was assessed in mothers during pregnancy, and vitamin supplementation use was assessed for children, including formation regarding type, frequency, and duration of vitamin supplementation.

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Keywords	medication metabolism nutrition pregnancy supplements vitamins nutritional supplement vitamin supplement
Constructs	life history lifestyle
Waves	Young Netherlands Twin Register YS_1 MM 0 months - 12 months From 1987-01-01 (ongoing) YC_ACTION BB2 PC 6.0 - 11.0 years From 2015-01-01 to 2015-01-01 YC_ACTION - BB3 PC 6.0 - 13.0 years From 2016-01-01 to 2017-01-01 YE_COG18 MM 18.0 years From 2004-01-01 to 2006-01-01 YS_TRIP age 1 MM 12 months From 1990-01-01 to 2001-01-01 YS_TRIP age 1-2 MM 24 months - 38.0 years From 2008-01-01 (ongoing)
Mode of collection	SelfAdministeredQuestionnaire
Analysis unit	Individual

Purpose	The research carried out by the Netherlands Twin Register focuses on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.
description
Alternate title	NTR
Data access information	Researchers with an approved data sharing request who abide by the rules of the European General Data Protection Regulation can receive temporary access to the NTR data for their own research projects. https://ntr-data-request.psy.vu.nl/
Publisher	Vrije Universiteit Amsterdam
Principal investigators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Cohort study international identifier
Language	NL
Funding information	Dutch Research Council 480-15-001/674 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 575-25-006 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 480-04-004 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 911-09-032 Funder identifier https://ror.org/04jsz6e67 Funder identifier type ROR Funder identifier type URI https://ror.org/ Funder award title Funder award URI
Contact information	NTR Data Management Vrije Universiteit Amsterdam ntr.datamanagement.fgb@vu.nl
References	Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420. Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212. van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620. Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148. Bartels M, van Beijsterveldt CE, Derks EM, Stroet TM, Polderman TJ, Hudziak JJ, Boomsma DI. Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. Twin Res Hum Genet. 2007 Feb;10(1):3-11. doi: 10.1375/twin.10.1.3.PMID: 17539360. Boomsma DI, Orlebeke JF, van Baal GC.Behav Genet. The Dutch Twin Register: growth data on weight and height. 1992 Mar;22(2):247-51. doi: 10.1007/BF01067004 Franić S, Dolan CV, van Beijsterveldt CE, Hulshoff Pol HE, Bartels M, Boomsma DI. Genetic and environmental stability of intelligence in childhood and adolescence. Twin Res Hum Genet. 2014 Jun;17(3):151-63. doi: 10.1017/thg.2014.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam
Time method	Longitudinal
Universe	The recruitment into the NTR is fully inclusive without any restrictions on enrolment. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR).

Alternate title	YNTR
Description	The Young Netherlands Twin Register (YNTR) consists of projects within the Netherlands Twin Register (NTR) that involve families with twins or other multiples under the age of 18.
Purpose	The purpose of the projects within the Young Netherlands Twin Register focus on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Language	NL
Cohort international identifier
Funding information	Dutch Research Council 480-15-001/674 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 575-25-006 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 480-04-004 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI Dutch Research Council 911-09-032 Funder identifier https://ror.org/04jsz6e67 ROR Identifier type URI https://ror.org/ Funder award title Funder award URI
Cohort reference papers
Classification
Contact information
Waves
Contributors	YNTR administration Vrije Universiteit Amsterdam
References	Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420. Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212. van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620. Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.
Country code	NL
Geographic location
Lowest geographic reference	postal code
Highest geographic reference	country
Cohort universe description	Families with twins or other multiples under the age of 18.
Analysis unit
Additional info (URL)
Additional information
Time method	Longitudinal.CohortEventBased

Measure was collected within the following wave(s):

YS_1 Wave

Wave alternate title	YNTR survey age 1 YS_1
Short description of the wave	After registration of newborn twins, which is before the age of 12 months for 89% of the twins (mean age = 0.8 years, SD = 1.17 years), the mother of a twin pair receives the first survey which focuses on conception (spontaneous or otherwise), information from parents themselves (demographics, height, weight), pregnancy (e.g. duration, smoking and drinking behaviors of both parents during pregnancy), birth and health (malformations) of the children shortly after birth. The mother is asked to fill in this survey, and this was done by the biological mother for almost all of surveys with others (stepmother, adoptive mother, some fathers) completing this survey in a small number of families (<0.05%).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1987-01-01
End date wave collection
Wave universe description	0 months - 12 months
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2012) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YC_ACTION BB2 Wave

Wave alternate title	Biochemical Study ACTION Biomarker Study YC_ACTION
Short description of the wave	The biochemical study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the biochemical study was to further validate the biomarker assays and metabolomics platforms selected during the two waves of the technical pilot (YC_ACTION BB1_1 BB1_2) in a larger sample of 6-11 year old twins born between 2004 and 2009 (mean age = 9.9 years, SD = 1.6 years). The twins were selected based on their mother-rated aggression scores (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist) at age 3 and/or 7. The Biochemical study comprised concordant low-scoring twin pairs, concordant high-scoring twin pairs, and a discordant low-high scoring twin pairs. High aggression was defined as having an ASEBA CBCL Aggression Syndrome Scale T-score equal to or larger than 65, and low aggression as an ASEBA CBCL Aggression Syndrome Scale T-score of less than 65. Here, data collection comprised of first-morning urine samples and buccal-cell DNA samples in the twins and family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, oxidized DNA/RNA, procalcitonin, total antioxidant capacity, and glucose, and two metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; and 2) a LC-MS platform targeting steroid hormones. Buccal-cell samples were genotyped on the Affymetrix Axiom genotyping array.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2015-01-01
End date wave collection	2015-01-01
Wave universe description	6.0 - 11.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YC_ACTION - BB3 Wave

Wave alternate title	Main Study ACTION Biomarker Study YC_ACTION
Short description of the wave	The Main Study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu), after the technical pilots (YC_ACTION BB1_1 and BB1_2) and the Biochemical study (YC_ACTION BB2). Here, data collection of first-morning urine samples for metabolomics biomarker discovery and buccal-cell DNA samples for (epi)genetics was conducted in a large cohort of 6-13 year old twins born between 2004 and 2011 (mean age = 9.5 years, SD = 1.9 years). Family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. The twins were selected to be part of a concordant low-scoring twin pair, a concordant high-scoring twin pair, or a discordant twin pair. Aggression had been assessed in the past by the age-appropriate version of the CBCL (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist). During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, and oxidized DNA/RNA. Metabolomics data of the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were were obtained from three metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; 2) a LC-MS platform targeting steroid hormones; and 3) a gas chromatography (GC) MS platform targeting organic acids. Buccal-cell samples of the twins from the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were used for genome-wide methylation measurement on the Infinium MethylationEPIC BeadChip Kit (after conclussion of the ACTION project additional twin pairs and siblings were also measured on this platform). DNA samples from all family members were genotyped on the Affymetrix Axiom or Illumina GSA genotyping arrays.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam Bartels, Meike Vrije Universiteit Amsterdam
Funding information	602768 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title European Union Seventh Framework Program (FP7/2007–2013) Funder award URI
References	Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086. Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132. Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473. Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2016-01-01
End date wave collection	2017-01-01
Wave universe description	6.0 - 13.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hagenbeek, Fiona A. Vrije Universiteit Amsterdam Vandenbosch, Marjolein M.L.J.Z. Vrije Universiteit Amsterdam

YE_COG18 Wave

Wave alternate title	Cognitive abilities of 18-year-old twins YE_COG18
Short description of the wave	The YE_COG18 project is the fifth measurement of a longitudinal study into the development of intelligence and problem behaviour (waves one and two not included in this catalogue, wave 3: YE_COG10, wave 4: YE_COG12), to which additional participants were recruited (twins with siblings and their parents). It targeted 18-year old twins (mean age = 18.1 years, SD = 0.5 years) born between 1986 and 1991, their 8-35 year old siblings (mean age = 18.8 years, SD = 4.9 years) born between 1970 and 1998, and their parents (mean age = 48.9 years, SD = 4.14 years) born between 1942 and 1965. The test protocol consisted of a physical part and a psychological part. Physical measurements included cardiovascular functioning (assessed with the VU-AMS device), a physical examination with basic anthropometric measurements and the collection of saliva, DNA and fingerprints. The psychological part consisted of a series of cognitive tests that measured the following abilities: intelligence (Wechsler Intelligence Scale for Children, WISC-R or Revised Amsterdamse Kinder Intelligentie Test, RAKIT); inhibition (Stroop); spontaneous production of words (Verbal fluency); verbal learning and memory (California Verbal Learning Task, CVLT); emotion recognition (Reading the mind in the eyes); perceptual speed (Π inspection time task); spatial short term memory (n-back task and Corsi block tapping task). Furthermore, some questionnaires were administered to the participants (Autism-Spectrum Quotient, Tanner self-report), mothers of the twins (Social Responsiveness Scale) and research assistants (Test Observation form).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information	56-464-14192 Funder identifier ROR Identifier type URI https://ror.org/ Funder award title Spinoza Prize Funder award URI
References	Hoekstra, R. A. (2007). Autistic traits, withdrawn behaviour and cognition: a longitudinal twin study from early childhood to young adulthood. https://research.vu.nl/en/publications/autistic-traits-withdrawn-behaviour-and-cognition-a-longitudinal-. Estourgie-van Burk, G. F. (2011). Variation in growth and the influence of early growth in later life: a twin-sibling study. https://research.vu.nl/en/publications/variation-in-growth-and-the-influence-of-early-growth-in-later-li. ISBN: 9789086595532.
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2004-01-01
End date wave collection	2006-01-01
Wave universe description	18.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	Hoekstra, Rosa A. Vrije Universiteit Amsterdam Estourgie-van Burk, Frederiek Vrije Universiteit Amsterdam

YS_TRIP age 1 Wave

Wave alternate title	Triplet survey age 1 YS_TRIP
Short description of the wave	The YNTR survey for triplets at age 1 (mean age = 1.35 years, SD = 1.39 years, born between 1987 and 2005) was a 2-page survey that included items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, and mode of delivery. The content of this survey is highly comparable with the survey 1 for twins (YS_1).
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	1990-01-01
End date wave collection	2001-01-01
Wave universe description	12 months
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

YS_TRIP age 1-2 Wave

Wave alternate title	Triplet survey age 1-2 YS_TRIP
Short description of the wave	In 2008, a combination of the triplet surveys at age 1 and 2 was sent to mothers of all triplets in both YNTR and ANTR. The survey was sent to 535 mothers and was returned by 264 mothers (triplet ages ranged between 2 and 38 years, mean age = 11.9, SD = 7.0). Since 2009, the combined survey 1 and 2 serves as the first survey for newly registered triplets at age 2. The combined survey comprises items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, mode of delivery, breastfeeding, attaining milestones, and growth.
Type of StudyUnit
Publisher	Vrije Universiteit Amsterdam
Creators	Boomsma, Dorret I. Vrije Universiteit Amsterdam
Funding information
References
(sub) cohort	NTR: Young Netherlands Twin Register
Life stage
Coverage percentage of the measurement for this wave
Start date wave collection	2008-01-01
End date wave collection
Wave universe description	24 months - 38.0 years
Stage of measurement
Language	NL
Description of physical data product	Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived.
Additional info (URL)
Additional information
Contributors	YNTR administration Vrije Universiteit Amsterdam

You can also access this dataset using the API (see API Docs).

author	None
author_email	None
creator_user_id	34768773-4537-4d74-8d9d-11e2b32cbbaf
dc_analysis_unit	{Individual}
dc_cohort	NTR
id	a1c261d4-87d1-4ad6-a01f-1be2c2bf39ed
isopen	False
license_title	None
maintainer	None
maintainer_email	None
metadata_created	2024-10-17T12:43:04.903995
metadata_modified	2024-10-20T12:54:30.430284
name	bd803fc5bf747f8af1ccf57bfc0085f3
notes	Nutritional supplement use was assessed in mothers during pregnancy, and vitamin supplementation use was assessed for children, including formation regarding type, frequency, and duration of vitamin supplementation.
num_resources	0
num_tags	0
organization	{'id': '45b26247-5cc8-4bf1-a214-3efb773faa3a', 'name': 'ntr', 'title': 'Netherlands Twin Register', 'type': 'organization', 'description': 'The Netherlands Twin Register (NTR) consists of individuals who have agreed to participate in twin-family studies and was established and is managed by the Department of Biological Psychology, VU University Amsterdam (see: https://tweelingenregister.vu.nl/). The NTR was established in 1987 and has enrolled around 120.000 twins and a roughly equal number of their relatives. The majority of twin families have participated one or more times in survey studies on a host of epidemiological variables including social demography, personality, lifestyle, somatic and mental health, and subsamples took part in biomaterial collection (e.g. DNA) and dedicated projects for e.g. neuropsychological, biomarker, and behavioral traits. The recruitment into the NTR is fully inclusive without any restrictions on enrolment. The NTR is committed to actively seek the commitment of its participants to science and their continued involvement in NTR research by maintaining a website, electronic newsletters, and the MijnNTR portal that provides personalized feedback to participants. The NTR resources, e.g. the longitudinal phenotyping, the extended pedigree structures, and the multi-generation genotyping allow for future twin-family research that will contribute to gene discovery, causality modelling, and studies of genetic and cultural inheritance of behavioral traits and mental and physical health. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR).', 'image_url': 'https://data.individualdevelopment.nl/img/logo_ntr.png', 'created': '2024-10-17T13:43:56.356410', 'is_organization': True, 'approval_status': 'approved', 'state': 'active'}
owner_org	45b26247-5cc8-4bf1-a214-3efb773faa3a
private	False
state	active
title	Supplement use
type	measure
cohort	[{'cohort_alternate_title': 'YNTR', 'cohort_description': 'The Young Netherlands Twin Register (YNTR) consists of projects within the Netherlands Twin Register (NTR) that involve families with twins or other multiples under the age of 18.', 'cohort_language': 'NL', 'cohort_purpose': 'The purpose of the projects within the Young Netherlands Twin Register focus on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.', 'cohort_spatial_country_code': 'NL', 'cohort_spatial_highest_reference': 'country', 'cohort_spatial_lowest_reference': 'postal code', 'cohort_time_method': 'Longitudinal.CohortEventBased', 'cohort_title': 'NTR: Young Netherlands Twin Register', 'cohort_universe': 'Families with twins or other multiples under the age of 18.', 'cohort_contributor': [{'cohort_contributor': 'YNTR administration', 'cohort_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'cohort_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'cohort_contributor_affiliation_identifier_scheme': 'ROR', 'cohort_contributor_affiliation_identifier_schemeuri': 'https://ror.org/'}], 'cohort_creator': [{'cohort_creator_affiliation': 'Vrije Universiteit Amsterdam', 'cohort_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'cohort_creator_affiliation_identifier_scheme': 'ROR', 'cohort_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'cohort_creator_identifier_schemeuri': 'https://orcid.org/', 'cohort_creator_identifier_type': 'ORCID', 'cohort_creator_name': 'Boomsma, Dorret I.', 'cohort_creator_pid': '0000-0002-7099-7972'}], 'cohort_funding': [{'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '480-15-001/674'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '575-25-006'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '480-04-004'}, {'cohort_funder': 'Dutch Research Council', 'cohort_funder_identifier': 'https://ror.org/04jsz6e67', 'cohort_funder_identifier_schemuri': 'https://ror.org/', 'cohort_funder_identifier_type': 'ROR', 'cohort_grant_number': '911-09-032'}], 'cohort_publisher': [{'cohort_publisher_identifier': 'https://ror.org/008xxew50', 'cohort_publisher_identifier_type': 'ROR', 'cohort_publisher_name': 'Vrije Universiteit Amsterdam'}], 'cohort_references': [{'cohort_reference_citation': 'Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420.', 'cohort_reference_identifier': 'https://doi.org/10.1375/183242706779462426', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'cohort_reference_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': 'van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620.', 'cohort_reference_identifier': 'https://doi.org/10.1017/thg.2012.118', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}, {'cohort_reference_citation': "Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.", 'cohort_reference_identifier': 'https://doi.org/10.1017/thg.2019.93', 'cohort_reference_identifier_type': 'DOI', 'cohort_reference_type': 'IsDescribedBy'}]}]
dc_DOI	[{'dc_identifier_type': 'DOI', 'dc_pid': '10.60641/17bf-vg61'}]
dc_constructs	[{'dc_construct': 'life history'}, {'dc_construct': 'lifestyle'}]
dc_labels	[{'dc_label': 'medication'}, {'dc_label': 'metabolism'}, {'dc_label': 'nutrition'}, {'dc_label': 'pregnancy'}, {'dc_label': 'supplements'}, {'dc_label': 'vitamins'}, {'dc_label': 'nutritional supplement'}, {'dc_label': 'vitamin supplement'}]
dc_modes_of_collection	[{'dc_mode_of_collection': 'SelfAdministeredQuestionnaire'}]
measure_age_range	[{'measure_age_month': 0}, {'measure_age_month': 1}, {'measure_age_month': 2}, {'measure_age_month': 3}, {'measure_age_month': 4}, {'measure_age_month': 5}, {'measure_age_month': 6}, {'measure_age_month': 7}, {'measure_age_month': 8}, {'measure_age_month': 9}, {'measure_age_month': 10}, {'measure_age_month': 11}, {'measure_age_month': 12}, {'measure_age_month': 24}, {'measure_age_month': 25}, {'measure_age_month': 26}, {'measure_age_month': 27}, {'measure_age_month': 28}, {'measure_age_month': 29}, {'measure_age_month': 30}, {'measure_age_month': 31}, {'measure_age_month': 32}, {'measure_age_month': 33}, {'measure_age_month': 34}, {'measure_age_month': 35}, {'measure_age_month': 36}, {'measure_age_month': 37}, {'measure_age_month': 38}, {'measure_age_month': 39}, {'measure_age_month': 40}, {'measure_age_month': 41}, {'measure_age_month': 42}, {'measure_age_month': 43}, {'measure_age_month': 44}, {'measure_age_month': 45}, {'measure_age_month': 46}, {'measure_age_month': 47}, {'measure_age_month': 48}, {'measure_age_month': 49}, {'measure_age_month': 50}, {'measure_age_month': 51}, {'measure_age_month': 52}, {'measure_age_month': 53}, {'measure_age_month': 54}, {'measure_age_month': 55}, {'measure_age_month': 56}, {'measure_age_month': 57}, {'measure_age_month': 58}, {'measure_age_month': 59}, {'measure_age_month': 60}, {'measure_age_month': 61}, {'measure_age_month': 62}, {'measure_age_month': 63}, {'measure_age_month': 64}, {'measure_age_month': 65}, {'measure_age_month': 66}, {'measure_age_month': 67}, {'measure_age_month': 68}, {'measure_age_month': 69}, {'measure_age_month': 70}, {'measure_age_month': 71}, {'measure_age_month': 72}, {'measure_age_month': 73}, {'measure_age_month': 74}, {'measure_age_month': 75}, {'measure_age_month': 76}, {'measure_age_month': 77}, {'measure_age_month': 78}, {'measure_age_month': 79}, {'measure_age_month': 80}, {'measure_age_month': 81}, {'measure_age_month': 82}, {'measure_age_month': 83}, {'measure_age_month': 84}, {'measure_age_month': 85}, {'measure_age_month': 86}, {'measure_age_month': 87}, {'measure_age_month': 88}, {'measure_age_month': 89}, {'measure_age_month': 90}, {'measure_age_month': 91}, {'measure_age_month': 92}, {'measure_age_month': 93}, {'measure_age_month': 94}, {'measure_age_month': 95}, {'measure_age_month': 96}, {'measure_age_month': 97}, {'measure_age_month': 98}, {'measure_age_month': 99}, {'measure_age_month': 100}, {'measure_age_month': 101}, {'measure_age_month': 102}, {'measure_age_month': 103}, {'measure_age_month': 104}, {'measure_age_month': 105}, {'measure_age_month': 106}, {'measure_age_month': 107}, {'measure_age_month': 108}, {'measure_age_month': 109}, {'measure_age_month': 110}, {'measure_age_month': 111}, {'measure_age_month': 112}, {'measure_age_month': 113}, {'measure_age_month': 114}, {'measure_age_month': 115}, {'measure_age_month': 116}, {'measure_age_month': 117}, {'measure_age_month': 118}, {'measure_age_month': 119}, {'measure_age_month': 120}, {'measure_age_month': 121}, {'measure_age_month': 122}, {'measure_age_month': 123}, {'measure_age_month': 124}, {'measure_age_month': 125}, {'measure_age_month': 126}, {'measure_age_month': 127}, {'measure_age_month': 128}, {'measure_age_month': 129}, {'measure_age_month': 130}, {'measure_age_month': 131}, {'measure_age_month': 132}, {'measure_age_month': 133}, {'measure_age_month': 134}, {'measure_age_month': 135}, {'measure_age_month': 136}, {'measure_age_month': 137}, {'measure_age_month': 138}, {'measure_age_month': 139}, {'measure_age_month': 140}, {'measure_age_month': 141}, {'measure_age_month': 142}, {'measure_age_month': 143}, {'measure_age_month': 144}, {'measure_age_month': 145}, {'measure_age_month': 146}, {'measure_age_month': 147}, {'measure_age_month': 148}, {'measure_age_month': 149}, {'measure_age_month': 150}, {'measure_age_month': 151}, {'measure_age_month': 152}, {'measure_age_month': 153}, {'measure_age_month': 154}, {'measure_age_month': 155}, {'measure_age_month': 156}, {'measure_age_month': 157}, {'measure_age_month': 158}, {'measure_age_month': 159}, {'measure_age_month': 160}, {'measure_age_month': 161}, {'measure_age_month': 162}, {'measure_age_month': 163}, {'measure_age_month': 164}, {'measure_age_month': 165}, {'measure_age_month': 166}, {'measure_age_month': 167}, {'measure_age_month': 168}, {'measure_age_month': 169}, {'measure_age_month': 170}, {'measure_age_month': 171}, {'measure_age_month': 172}, {'measure_age_month': 173}, {'measure_age_month': 174}, {'measure_age_month': 175}, {'measure_age_month': 176}, {'measure_age_month': 177}, {'measure_age_month': 178}, {'measure_age_month': 179}, {'measure_age_month': 180}, {'measure_age_month': 181}, {'measure_age_month': 182}, {'measure_age_month': 183}, {'measure_age_month': 184}, {'measure_age_month': 185}, {'measure_age_month': 186}, {'measure_age_month': 187}, {'measure_age_month': 188}, {'measure_age_month': 189}, {'measure_age_month': 190}, {'measure_age_month': 191}, {'measure_age_month': 192}, {'measure_age_month': 193}, {'measure_age_month': 194}, {'measure_age_month': 195}, {'measure_age_month': 196}, {'measure_age_month': 197}, {'measure_age_month': 198}, {'measure_age_month': 199}, {'measure_age_month': 200}, {'measure_age_month': 201}, {'measure_age_month': 202}, {'measure_age_month': 203}, {'measure_age_month': 204}, {'measure_age_month': 205}, {'measure_age_month': 206}, {'measure_age_month': 207}, {'measure_age_month': 208}, {'measure_age_month': 209}, {'measure_age_month': 210}, {'measure_age_month': 211}, {'measure_age_month': 212}, {'measure_age_month': 213}, {'measure_age_month': 214}, {'measure_age_month': 215}, {'measure_age_month': 216}, {'measure_age_month': 217}, {'measure_age_month': 218}, {'measure_age_month': 219}, {'measure_age_month': 220}, {'measure_age_month': 221}, {'measure_age_month': 222}, {'measure_age_month': 223}, {'measure_age_month': 224}, {'measure_age_month': 225}, {'measure_age_month': 226}, {'measure_age_month': 227}, {'measure_age_month': 228}, {'measure_age_month': 229}, {'measure_age_month': 230}, {'measure_age_month': 231}, {'measure_age_month': 232}, {'measure_age_month': 233}, {'measure_age_month': 234}, {'measure_age_month': 235}, {'measure_age_month': 236}, {'measure_age_month': 237}, {'measure_age_month': 238}, {'measure_age_month': 239}, {'measure_age_month': 240}, {'measure_age_month': 241}, {'measure_age_month': 242}, {'measure_age_month': 243}, {'measure_age_month': 244}, {'measure_age_month': 245}, {'measure_age_month': 246}, {'measure_age_month': 247}, {'measure_age_month': 248}, {'measure_age_month': 249}, {'measure_age_month': 250}, {'measure_age_month': 251}, {'measure_age_month': 252}, {'measure_age_month': 253}, {'measure_age_month': 254}, {'measure_age_month': 255}, {'measure_age_month': 256}, {'measure_age_month': 257}, {'measure_age_month': 258}, {'measure_age_month': 259}, {'measure_age_month': 260}, {'measure_age_month': 261}, {'measure_age_month': 262}, {'measure_age_month': 263}, {'measure_age_month': 264}, {'measure_age_month': 265}, {'measure_age_month': 266}, {'measure_age_month': 267}, {'measure_age_month': 268}, {'measure_age_month': 269}, {'measure_age_month': 270}, {'measure_age_month': 271}, {'measure_age_month': 272}, {'measure_age_month': 273}, {'measure_age_month': 274}, {'measure_age_month': 275}, {'measure_age_month': 276}, {'measure_age_month': 277}, {'measure_age_month': 278}, {'measure_age_month': 279}, {'measure_age_month': 280}, {'measure_age_month': 281}, {'measure_age_month': 282}, {'measure_age_month': 283}, {'measure_age_month': 284}, {'measure_age_month': 285}, {'measure_age_month': 286}, {'measure_age_month': 287}, {'measure_age_month': 288}, {'measure_age_month': 289}, {'measure_age_month': 290}, {'measure_age_month': 291}, {'measure_age_month': 292}, {'measure_age_month': 293}, {'measure_age_month': 294}, {'measure_age_month': 295}, {'measure_age_month': 296}, {'measure_age_month': 297}, {'measure_age_month': 298}, {'measure_age_month': 299}, {'measure_age_month': 300}, {'measure_age_month': 301}, {'measure_age_month': 302}, {'measure_age_month': 303}, {'measure_age_month': 304}, {'measure_age_month': 305}, {'measure_age_month': 306}, {'measure_age_month': 307}, {'measure_age_month': 308}, {'measure_age_month': 309}, {'measure_age_month': 310}, {'measure_age_month': 311}, {'measure_age_month': 312}, {'measure_age_month': 313}, {'measure_age_month': 314}, {'measure_age_month': 315}, {'measure_age_month': 316}, {'measure_age_month': 317}, {'measure_age_month': 318}, {'measure_age_month': 319}, {'measure_age_month': 320}, {'measure_age_month': 321}, {'measure_age_month': 322}, {'measure_age_month': 323}, {'measure_age_month': 324}, {'measure_age_month': 325}, {'measure_age_month': 326}, {'measure_age_month': 327}, {'measure_age_month': 328}, {'measure_age_month': 329}, {'measure_age_month': 330}, {'measure_age_month': 331}, {'measure_age_month': 332}, {'measure_age_month': 333}, {'measure_age_month': 334}, {'measure_age_month': 335}, {'measure_age_month': 336}, {'measure_age_month': 337}, {'measure_age_month': 338}, {'measure_age_month': 339}, {'measure_age_month': 340}, {'measure_age_month': 341}, {'measure_age_month': 342}, {'measure_age_month': 343}, {'measure_age_month': 344}, {'measure_age_month': 345}, {'measure_age_month': 346}, {'measure_age_month': 347}, {'measure_age_month': 348}, {'measure_age_month': 349}, {'measure_age_month': 350}, {'measure_age_month': 351}, {'measure_age_month': 352}, {'measure_age_month': 353}, {'measure_age_month': 354}, {'measure_age_month': 355}, {'measure_age_month': 356}, {'measure_age_month': 357}, {'measure_age_month': 358}, {'measure_age_month': 359}, {'measure_age_month': 360}, {'measure_age_month': 361}, {'measure_age_month': 362}, {'measure_age_month': 363}, {'measure_age_month': 364}, {'measure_age_month': 365}, {'measure_age_month': 366}, {'measure_age_month': 367}, {'measure_age_month': 368}, {'measure_age_month': 369}, {'measure_age_month': 370}, {'measure_age_month': 371}, {'measure_age_month': 372}, {'measure_age_month': 373}, {'measure_age_month': 374}, {'measure_age_month': 375}, {'measure_age_month': 376}, {'measure_age_month': 377}, {'measure_age_month': 378}, {'measure_age_month': 379}, {'measure_age_month': 380}, {'measure_age_month': 381}, {'measure_age_month': 382}, {'measure_age_month': 383}, {'measure_age_month': 384}, {'measure_age_month': 385}, {'measure_age_month': 386}, {'measure_age_month': 387}, {'measure_age_month': 388}, {'measure_age_month': 389}, {'measure_age_month': 390}, {'measure_age_month': 391}, {'measure_age_month': 392}, {'measure_age_month': 393}, {'measure_age_month': 394}, {'measure_age_month': 395}, {'measure_age_month': 396}, {'measure_age_month': 397}, {'measure_age_month': 398}, {'measure_age_month': 399}, {'measure_age_month': 400}, {'measure_age_month': 401}, {'measure_age_month': 402}, {'measure_age_month': 403}, {'measure_age_month': 404}, {'measure_age_month': 405}, {'measure_age_month': 406}, {'measure_age_month': 407}, {'measure_age_month': 408}, {'measure_age_month': 409}, {'measure_age_month': 410}, {'measure_age_month': 411}, {'measure_age_month': 412}, {'measure_age_month': 413}, {'measure_age_month': 414}, {'measure_age_month': 415}, {'measure_age_month': 416}, {'measure_age_month': 417}, {'measure_age_month': 418}, {'measure_age_month': 419}, {'measure_age_month': 420}, {'measure_age_month': 421}, {'measure_age_month': 422}, {'measure_age_month': 423}, {'measure_age_month': 424}, {'measure_age_month': 425}, {'measure_age_month': 426}, {'measure_age_month': 427}, {'measure_age_month': 428}, {'measure_age_month': 429}, {'measure_age_month': 430}, {'measure_age_month': 431}, {'measure_age_month': 432}, {'measure_age_month': 433}, {'measure_age_month': 434}, {'measure_age_month': 435}, {'measure_age_month': 436}, {'measure_age_month': 437}, {'measure_age_month': 438}, {'measure_age_month': 439}, {'measure_age_month': 440}, {'measure_age_month': 441}, {'measure_age_month': 442}, {'measure_age_month': 443}, {'measure_age_month': 444}, {'measure_age_month': 445}, {'measure_age_month': 446}, {'measure_age_month': 447}, {'measure_age_month': 448}, {'measure_age_month': 449}, {'measure_age_month': 450}, {'measure_age_month': 451}, {'measure_age_month': 452}, {'measure_age_month': 453}, {'measure_age_month': 454}, {'measure_age_month': 455}, {'measure_age_month': 456}]
study	[{'study_alternate_title': 'NTR', 'study_language': 'NL', 'study_purpose': 'The research carried out by the Netherlands Twin Register focuses on the role of heritability in mental and physical health. For instance, the NTR investigates why some people become more easily depressed than others, or why certain people get diabetes while others do not. Other research areas include lifestyle and habits that influence health and disease, such as smoking, drinking and exercise.', 'study_time_method': 'Longitudinal', 'study_universe': 'The recruitment into the NTR is fully inclusive without any restrictions on enrolment. In the CID data catalogue, only the NTR projects for children and adolescents (<18 years of age) have been included. This is refered to as the Young Netherlands Twin Register (YNTR). ', 'title': 'Netherlands Twin Register', 'study_contact': [{'study_contact_affiliation': 'Vrije Universiteit Amsterdam', 'study_contact_mail': 'ntr.datamanagement.fgb@vu.nl', 'study_contact_name': 'NTR Data Management'}], 'study_contributor': [{'study_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'study_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'study_contributor_affiliation_identifier_scheme': 'ROR', 'study_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_contributor_name': 'YNTR administration'}], 'study_data_access': [{'study_data_access_URL': 'https://ntr-data-request.psy.vu.nl/', 'study_data_access_description': 'Researchers with an approved data sharing request who abide by the rules of the European General Data Protection Regulation can receive temporary access to the NTR data for their own research projects.'}], 'study_funding': [{'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '480-15-001/674'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '575-25-006'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '480-04-004'}, {'study_funder': 'Dutch Research Council', 'study_funder_identifier': 'https://ror.org/04jsz6e67', 'study_funder_identifier_schemuri': 'https://ror.org/', 'study_funder_identifier_type': 'ROR', 'study_grant_number': '911-09-032'}], 'study_principal_investigators': [{'study_pi_affiliation': 'Vrije Universiteit Amsterdam', 'study_pi_affiliation_identifier': 'https://ror.org/008xxew50', 'study_pi_affiliation_identifier_scheme': 'ROR', 'study_pi_affiliation_identifier_schemeuri': 'https://ror.org/', 'study_pi_identifier_schemeuri': 'https://orcid.org/', 'study_pi_identifier_type': 'ORCID', 'study_pi_name': 'Boomsma, Dorret I.', 'study_pi_pid': '0000-0002-7099-7972'}], 'study_publisher': [{'study_publisher_identifier': 'https://ror.org/008xxew50', 'study_publisher_identifier_schemeuri': 'https://ror.org/', 'study_publisher_identifier_type': 'ROR', 'study_publisher_name': 'Vrije Universiteit Amsterdam'}], 'study_references': [{'study_reference_citation': 'Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006 Dec;9(6):849-57. doi: 10.1375/183242706779462426. PMID: 17254420.', 'study_reference_identifier': 'https://doi.org/10.1375/183242706779462426', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Boomsma DI, Willemsen G, Vink JM, Bartels M, Groot P, Hottenga JJ, van Beijsterveldt CE, Stroet T, van Dijk R, Wertheim R, Visser M, van der Kleij F. Design and implementation of a twin-family database for behavior genetics and genomics studies. Twin Res Hum Genet. 2008 Jun;11(3):342-8. doi: 10.1375/twin.11.3.342. PMID: 18498212.', 'study_reference_identifier': 'https://doi.org/10.1375/twin.11.3.342', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franić S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davies GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): longitudinal twin and family studies in over 70,000 children. Twin Res Hum Genet. 2013 Feb;16(1):252-67. doi: 10.1017/thg.2012.118. Epub 2012 Nov 28. PMID: 23186620.', 'study_reference_identifier': 'https://doi.org/10.1017/thg.2012.118', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': "Ligthart L, van Beijsterveldt CEM, Kevenaar ST, de Zeeuw E, van Bergen E, Bruins S, Pool R, Helmer Q, van Dongen J, Hottenga JJ, Van't Ent D, Dolan CV, Davies GE, Ehli EA, Bartels M, Willemsen G, de Geus EJC, Boomsma DI. The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs. Twin Res Hum Genet. 2019 Dec;22(6):623-636. doi: 10.1017/thg.2019.93. Epub 2019 Oct 31. PMID: 31666148.", 'study_reference_identifier': 'https://doi.org/10.1017/thg.2019.93', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Bartels M, van Beijsterveldt CE, Derks EM, Stroet TM, Polderman TJ, Hudziak JJ, Boomsma DI. Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. Twin Res Hum Genet. 2007 Feb;10(1):3-11. doi: 10.1375/twin.10.1.3.PMID: 17539360.', 'study_reference_identifier': 'https://doi.org/10.1375/twin.10.1.3', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Boomsma DI, Orlebeke JF, van Baal GC.Behav Genet. The Dutch Twin Register: growth data on weight and height. 1992 Mar;22(2):247-51. doi: 10.1007/BF01067004', 'study_reference_identifier': 'https://doi.org/10.1007/BF01067004', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}, {'study_reference_citation': 'Franić S, Dolan CV, van Beijsterveldt CE, Hulshoff Pol HE, Bartels M, Boomsma DI. Genetic and environmental stability of intelligence in childhood and adolescence. Twin Res Hum Genet. 2014 Jun;17(3):151-63. doi: 10.1017/thg.2014.', 'study_reference_identifier': 'https://doi.org/10.1017/thg.2014', 'study_reference_identifier_type': 'DOI', 'study_reference_type': 'IsDescribedBy'}]}]
wave	[{'wave_alternate_title': 'YNTR survey age 1 [YS_1]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'After registration of newborn twins, which is before the age of 12 months for 89% of the twins (mean age = 0.8 years, SD = 1.17 years), the mother of a twin pair receives the first survey which focuses on conception (spontaneous or otherwise), information from parents themselves (demographics, height, weight), pregnancy (e.g. duration, smoking and drinking behaviors of both parents during pregnancy), birth and health (malformations) of the children shortly after birth. The mother is asked to fill in this survey, and this was done by the biological mother for almost all of surveys with others (stepmother, adoptive mother, some fathers) completing this survey in a small number of families (<0.05%).', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2012) have been scanned. All data digitally archived.', 'wave_start_date_collection': '1987-01-01', 'wave_title': 'YS_1', 'wave_universe': '0-12', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MM', 'wave_subject_code_translated': 'Mother (biological or non-biological) on self'}]}, {'wave_alternate_title': 'Biochemical Study ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The biochemical study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu). The aim of the biochemical study was to further validate the biomarker assays and metabolomics platforms selected during the two waves of the technical pilot (YC_ACTION BB1_1 BB1_2) in a larger sample of 6-11 year old twins born between 2004 and 2009 (mean age = 9.9 years, SD = 1.6 years). The twins were selected based on their mother-rated aggression scores (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist) at age 3 and/or 7. The Biochemical study comprised concordant low-scoring twin pairs, concordant high-scoring twin pairs, and a discordant low-high scoring twin pairs. High aggression was defined as having an ASEBA CBCL Aggression Syndrome Scale T-score equal to or larger than 65, and low aggression as an ASEBA CBCL Aggression Syndrome Scale T-score of less than 65. Here, data collection comprised of first-morning urine samples and buccal-cell DNA samples in the twins and family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, oxidized DNA/RNA, procalcitonin, total antioxidant capacity, and glucose, and two metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; and 2) a LC-MS platform targeting steroid hormones. Buccal-cell samples were genotyped on the Affymetrix Axiom genotyping array. ', 'wave_end_date_collection': '2015-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2015-01-01', 'wave_title': 'YC_ACTION BB2', 'wave_universe': '72-132', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'PC', 'wave_subject_code_translated': 'Parent (biological and non-biological, incl. caregivers) on Child'}]}, {'wave_alternate_title': 'Main Study ACTION Biomarker Study [YC_ACTION]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The Main Study of the ACTION project (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and interventION strategies Consortium; http://www.action-euproject.eu), after the technical pilots (YC_ACTION BB1_1 and BB1_2) and the Biochemical study (YC_ACTION BB2). Here, data collection of first-morning urine samples for metabolomics biomarker discovery and buccal-cell DNA samples for (epi)genetics was conducted in a large cohort of 6-13 year old twins born between 2004 and 2011 (mean age = 9.5 years, SD = 1.9 years). Family members living at the same address as the participating twin pairs were also asked to provide a buccal-cell DNA sample. The twins were selected to be part of a concordant low-scoring twin pair, a concordant high-scoring twin pair, or a discordant twin pair. Aggression had been assessed in the past by the age-appropriate version of the CBCL (Achenbach System of Empirically Based Assessment (ASEBA) Child Behavior Checklist). During the urine and buccal-cell collection, parents of the twins were asked to complete the ASEBA CBCL for school-aged children (6-18 years) to reflect the current child behaviors, and to provide information about health condition of the twins and conditions of urine collection. Biochemical measurement in urine included a dipstick, density (specific gravity), creatinine, neopterin, C-peptide, Substance P, and oxidized DNA/RNA. Metabolomics data of the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were were obtained from three metabolomics platforms: 1) a liquid chromatography mass spectrometry (LC-MS) platform targeting amines; 2) a LC-MS platform targeting steroid hormones; and 3) a gas chromatography (GC) MS platform targeting organic acids. Buccal-cell samples of the twins from the Main Study together with the samples obtained in the Biochemical Study (ACTIONBB2) were used for genome-wide methylation measurement on the Infinium MethylationEPIC BeadChip Kit (after conclussion of the ACTION project additional twin pairs and siblings were also measured on this platform). DNA samples from all family members were genotyped on the Affymetrix Axiom or Illumina GSA genotyping arrays.', 'wave_end_date_collection': '2017-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2016-01-01', 'wave_title': 'YC_ACTION - BB3', 'wave_universe': '72-156', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hagenbeek, Fiona A.', 'wave_contributor_pid': '0000-0002-8773-0430'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Vandenbosch, Marjolein M.L.J.Z.', 'wave_contributor_pid': '0000-0002-7663-1744'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}, {'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Bartels, Meike', 'wave_creator_pid': '0000-0002-9667-7555'}], 'wave_funding': [{'wave_funder_award_title': 'European Union Seventh Framework Program (FP7/2007–2013)', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '602768'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Conde LC, Luningham J, Fung Ip H, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard M, van Dongen J, Lu Y, Middeldorp C, van Beijsterveldt T, Vermeiren R, Hankemeijer T, Kluft C, Medland S, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project. Eur Child Adolesc Psychiatry. 2018 Sep;27(9):1105-1121. doi: 10.1007/s00787-018-1169-1. Epub 2018 May 29. PMID: 29845340; PMCID: PMC6133086.', 'wave_references_identifier': 'https://doi.org/10.1007/s00787-018-1169-1', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek FA, Roetman PJ, Pool R, Kluft C, Harms AC, van Dongen J, Colins OF, Talens S, van Beijsterveldt CEM, Vandenbosch MMLJZ, de Zeeuw EL, Déjean S, Fanos V, Ehli EA, Davies GE, Hottenga JJ, Hankemeier T, Bartels M, Vermeiren RRJM, Boomsma DI. Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Front Psychiatry. 2020 Mar 31;11:165. doi: 10.3389/fpsyt.2020.00165. PMID: 32296350; PMCID: PMC7138132.', 'wave_references_identifier': 'https://doi.org/10.3389/fpsyt.2020.00165', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Hagenbeek, F. A. (2022). Omics, Biomarkers, and Aggressive Behavior. https://research.vu.nl/en/publications/omics-biomarkers-and-aggressive-behavior. ISBN: 9789493270473.', 'wave_references_identifier': 'https://hdl.handle.net/1871.1/ff5055ee-113a-45f7-a40f-8a624cef4c84', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Boomsma DI. Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics. J Pediatr Neonat Individual Med. 2015;4(2):e040251. doi: 10.7363/040251', 'wave_references_identifier': 'https://doi.org/10.7363/040251', 'wave_references_identifier_type': 'DOI', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'PC', 'wave_subject_code_translated': 'Parent (biological and non-biological, incl. caregivers) on Child'}]}, {'wave_alternate_title': 'Cognitive abilities of 18-year-old twins [YE_COG18]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YE_COG18 project is the fifth measurement of a longitudinal study into the development of intelligence and problem behaviour (waves one and two not included in this catalogue, wave 3: YE_COG10, wave 4: YE_COG12), to which additional participants were recruited (twins with siblings and their parents). It targeted 18-year old twins (mean age = 18.1 years, SD = 0.5 years) born between 1986 and 1991, their 8-35 year old siblings (mean age = 18.8 years, SD = 4.9 years) born between 1970 and 1998, and their parents (mean age = 48.9 years, SD = 4.14 years) born between 1942 and 1965. The test protocol consisted of a physical part and a psychological part. Physical measurements included cardiovascular functioning (assessed with the VU-AMS device), a physical examination with basic anthropometric measurements and the collection of saliva, DNA and fingerprints. The psychological part consisted of a series of cognitive tests that measured the following abilities: intelligence (Wechsler Intelligence Scale for Children, WISC-R or Revised Amsterdamse Kinder Intelligentie Test, RAKIT); inhibition (Stroop); spontaneous production of words (Verbal fluency); verbal learning and memory (California Verbal Learning Task, CVLT); emotion recognition (Reading the mind in the eyes); perceptual speed (Π inspection time task); spatial short term memory (n-back task and Corsi block tapping task). Furthermore, some questionnaires were administered to the participants (Autism-Spectrum Quotient, Tanner self-report), mothers of the twins (Social Responsiveness Scale) and research assistants (Test Observation form).', 'wave_end_date_collection': '2006-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2004-01-01', 'wave_title': 'YE_COG18', 'wave_universe': '216', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Hoekstra, Rosa A.', 'wave_contributor_pid': '0000-0002-1333-9762'}, {'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_identifier_schemeuri': 'https://orcid.org/', 'wave_contributor_identifier_type': 'ORCID', 'wave_contributor_name': 'Estourgie-van Burk, Frederiek', 'wave_contributor_pid': '0000-0001-7562-641X'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_funding': [{'wave_funder_award_title': 'Spinoza Prize', 'wave_funder_identifier_schemuri': 'https://ror.org/', 'wave_funder_identifier_type': 'ROR', 'wave_grant_number': '56-464-14192'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_references': [{'wave_references_citation': 'Hoekstra, R. A. (2007). Autistic traits, withdrawn behaviour and cognition: a longitudinal twin study from early childhood to young adulthood. https://research.vu.nl/en/publications/autistic-traits-withdrawn-behaviour-and-cognition-a-longitudinal-.', 'wave_references_identifier': 'https://hdl.handle.net/1871/33194', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}, {'wave_references_citation': 'Estourgie-van Burk, G. F. (2011). Variation in growth and the influence of early growth in later life: a twin-sibling study. https://research.vu.nl/en/publications/variation-in-growth-and-the-influence-of-early-growth-in-later-li. ISBN: 9789086595532.', 'wave_references_identifier': 'https://hdl.handle.net/1871/19635', 'wave_references_identifier_type': 'Handle', 'wave_references_type': 'IsDescribedBy'}], 'wave_subject_codes': [{'wave_subject_code': 'MM', 'wave_subject_code_translated': 'Mother (biological or non-biological) on self'}]}, {'wave_alternate_title': 'Triplet survey age 1 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'The YNTR survey for triplets at age 1 (mean age = 1.35 years, SD = 1.39 years, born between 1987 and 2005) was a 2-page survey that included items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, and mode of delivery. The content of this survey is highly comparable with the survey 1 for twins (YS_1).', 'wave_end_date_collection': '2001-01-01', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys have been scanned. All data digitally archived. ', 'wave_start_date_collection': '1990-01-01', 'wave_title': 'YS_TRIP age 1', 'wave_universe': '12', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MM', 'wave_subject_code_translated': 'Mother (biological or non-biological) on self'}]}, {'wave_alternate_title': 'Triplet survey age 1-2 [YS_TRIP]', 'wave_cohort': 'NTR: Young Netherlands Twin Register', 'wave_cohort_ckan_id': '6f88a94b0bf79a8304ba604c655c08a9', 'wave_description': 'In 2008, a combination of the triplet surveys at age 1 and 2 was sent to mothers of all triplets in both YNTR and ANTR. The survey was sent to 535 mothers and was returned by 264 mothers (triplet ages ranged between 2 and 38 years, mean age = 11.9, SD = 7.0). Since 2009, the combined survey 1 and 2 serves as the first survey for newly registered triplets at age 2. The combined survey comprises items on pregnancy, gestational age, smoking and alcohol consumption during pregnancy, mode of delivery, breastfeeding, attaining milestones, and growth.', 'wave_language': 'NL', 'wave_physical_data_product_description': 'Data collected through paper-and-pencil surveys (up to 2019) have been scanned. All data digitally archived. ', 'wave_start_date_collection': '2008-01-01', 'wave_title': 'YS_TRIP age 1-2', 'wave_universe': '24-456', 'wave_contributor': [{'wave_contributor_affiliation': 'Vrije Universiteit Amsterdam', 'wave_contributor_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_contributor_affiliation_identifier_scheme': 'ROR', 'wave_contributor_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_contributor_name': 'YNTR administration'}], 'wave_creator': [{'wave_creator_affiliation': 'Vrije Universiteit Amsterdam', 'wave_creator_affiliation_identifier': 'https://ror.org/008xxew50', 'wave_creator_affiliation_identifier_scheme': 'ROR', 'wave_creator_affiliation_identifier_schemeuri': 'https://ror.org/', 'wave_creator_identifier_schemeuri': 'https://orcid.org/', 'wave_creator_name': 'Boomsma, Dorret I.', 'wave_creator_pid': '0000-0002-7099-7972'}], 'wave_publisher': [{'wave_publisher_identifier': 'https://ror.org/008xxew50', 'wave_publisher_identifier_type': 'ROR', 'wave_publisher_name': 'Vrije Universiteit Amsterdam'}], 'wave_subject_codes': [{'wave_subject_code': 'MM', 'wave_subject_code_translated': 'Mother (biological or non-biological) on self'}]}]
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