LC-MS amines

Liquid chromatography mass spectrometry (LC-MS) platform targeting amines.

Urinary amine metabolites were measured using ultra-performance liquid chromatography tandem mass spectrometry (UPLCMS/MS). Chromatic separation was done on an Accq-Tag Ultra column (Waters Chromatography B.V., Etten – Leur, The Netherlands) using a UPLC Agilent Infinity II (1290 Multisampler, 1290 Multicolumn Thermostat and 1290 High Speed Pump Agilent Technologies, Waldbronn, Germany) coupled to an AB SCIEX quadrupole-ion trap (QTRAP AB Sciex, Massachusetts, USA). For more information see: https://doi.org/10.3389/fpsyt.2020.00165, https://doi.org/10.3390/metabo12060474 and https://doi.org/10.1007/s11306-011-0306-3.

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Keywords
Constructs
Waves
  • Young Netherlands Twin Register

  • YC_ACTION BB1_1
    •   C
    10.0 - 13.0 years   From 2014-01-01 to 2015-01-01
  • YC_ACTION BB1_2
    •   C
    10.0 - 13.0 years   From 2014-01-01 to 2015-01-01
  • YC_ACTION BB2
    •   C
    6.0 - 11.0 years   From 2015-01-01 to 2015-01-01
  • YC_ACTION - BB3
    •   C
    6.0 - 13.0 years   From 2016-01-01 to 2017-01-01
    Mode of collection MeasurementsAndTests    Biological sample/measurement
    Analysis unit Individual
    References
    Hagenbeek, F. A., Roetman, P. J., Pool, R., Kluft, C., Harms, A. C., van Dongen, J., Colins, O. F., Talens, S., van Beijsterveldt, C. E. M., Vandenbosch, M. M. L. J. Z., de Zeeuw, E. L., Déjean, S., Fanos, V., Ehli, E. A., Davies, G. E., Hottenga, J. J., Hankemeier, T., Bartels, M., Vermeiren, R. R. J. M., & Boomsma, D. I. (2020). Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.00165
    Hagenbeek, F. A., van Dongen, J., Pool, R., Harms, A. C., Roetman, P. J., Fanos, V., van Keulen, B. J., Walker, B. R., Karu, N., Hulshoff Pol, H. E., Rotteveel, J., Finken, M. J. J., Vermeiren, R. R. J. M., Kluft, C., Bartels, M., Hankemeier, T., & Boomsma, D. I. (2022). Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children. Metabolites, 12(6), 474. https://doi.org/10.3390/metabo12060474
    Noga, M. J., Dane, A., Shi, S., Attali, A., van Aken, H., Suidgeest, E., Tuinstra, T., Muilwijk, B., Coulier, L., Luider, T., Reijmers, T. H., Vreeken, R. J., & Hankemeier, T. (2011). Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics, 8(2), 253–263. https://doi.org/10.1007/s11306-011-0306-3
    You can also access this dataset using the API (see API Docs).